Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid
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2006
Authors
Kuntić, VesnaStanojević, Maja

Holclajtner-Antunović, Ivanka
Uskoković-Marković, Snežana

Mioč, Ubavka B.
Todorović, Marija R.
Jovanović, Tanja
Vukojević, Vladana

Article (Published version)

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Show full item recordAbstract
Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.
Keywords:
heteropoly compounds / amino acids / IR spectroscopy / cellular toxicity / antiviral activitySource:
Monatshefte für Chemie Chemical Monthly, 2006, 137, 6, 803-810Publisher:
- Springer Wien, Wien
Projects:
- Struktura, termodinamičke i elektrohemijske osobine materijala za konverziju energije i nove tehnologije (RS-142047)
- Supstance za farmaceutsku upotrebu: modeliranje, sinteza, fizičko-hemijske i biološke osobine, stepen čistoće i ispitivanje doziranih oblika (RS-142072)
DOI: 10.1007/s00706-006-0467-3
ISSN: 0026-9247