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Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid

Authorized Users Only
2006
Authors
Kuntić, Vesna
Stanojević, Maja
Holclajtner-Antunović, Ivanka
Uskoković-Marković, Snežana
Mioč, Ubavka B.
Todorović, Marija R.
Jovanović, Tanja
Vukojević, Vladana
Article (Published version)
Metadata
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Abstract
Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.
Keywords:
heteropoly compounds / amino acids / IR spectroscopy / cellular toxicity / antiviral activity
Source:
Monatshefte für Chemie Chemical Monthly, 2006, 137, 6, 803-810
Publisher:
  • Springer Wien, Wien
Funding / projects:
  • Struktura, termodinamičke i elektrohemijske osobine materijala za konverziju energije i nove tehnologije (RS-142047)
  • Supstance za farmaceutsku upotrebu: modeliranje, sinteza, fizičko-hemijske i biološke osobine, stepen čistoće i ispitivanje doziranih oblika (RS-142072)

DOI: 10.1007/s00706-006-0467-3

ISSN: 0026-9247

WoS: 000239791700012

Scopus: 2-s2.0-33745013371
[ Google Scholar ]
9
8
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/837
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Kuntić, Vesna
AU  - Stanojević, Maja
AU  - Holclajtner-Antunović, Ivanka
AU  - Uskoković-Marković, Snežana
AU  - Mioč, Ubavka B.
AU  - Todorović, Marija R.
AU  - Jovanović, Tanja
AU  - Vukojević, Vladana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/837
AB  - Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.
PB  - Springer Wien, Wien
T2  - Monatshefte für Chemie Chemical Monthly
T1  - Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid
VL  - 137
IS  - 6
SP  - 803
EP  - 810
DO  - 10.1007/s00706-006-0467-3
ER  - 
@article{
author = "Kuntić, Vesna and Stanojević, Maja and Holclajtner-Antunović, Ivanka and Uskoković-Marković, Snežana and Mioč, Ubavka B. and Todorović, Marija R. and Jovanović, Tanja and Vukojević, Vladana",
year = "2006",
abstract = "Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte für Chemie Chemical Monthly",
title = "Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid",
volume = "137",
number = "6",
pages = "803-810",
doi = "10.1007/s00706-006-0467-3"
}
Kuntić, V., Stanojević, M., Holclajtner-Antunović, I., Uskoković-Marković, S., Mioč, U. B., Todorović, M. R., Jovanović, T.,& Vukojević, V.. (2006). Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid. in Monatshefte für Chemie Chemical Monthly
Springer Wien, Wien., 137(6), 803-810.
https://doi.org/10.1007/s00706-006-0467-3
Kuntić V, Stanojević M, Holclajtner-Antunović I, Uskoković-Marković S, Mioč UB, Todorović MR, Jovanović T, Vukojević V. Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid. in Monatshefte für Chemie Chemical Monthly. 2006;137(6):803-810.
doi:10.1007/s00706-006-0467-3 .
Kuntić, Vesna, Stanojević, Maja, Holclajtner-Antunović, Ivanka, Uskoković-Marković, Snežana, Mioč, Ubavka B., Todorović, Marija R., Jovanović, Tanja, Vukojević, Vladana, "Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid" in Monatshefte für Chemie Chemical Monthly, 137, no. 6 (2006):803-810,
https://doi.org/10.1007/s00706-006-0467-3 . .

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