Morphological Study of Products Containing β‐Cyclodextrin

Abstract

β‐Cyclodextrin (β‐CD) has been applied in various fields of drug formulation. Its presence in powder Paracetamol (PAR) products prepared with different methods (kneading and spray drying) changes the morphology of original drug. The product made by spray drying has nearly isodimensional spherical particles, and potentially better flowability than the kneaded product. Spray drying of PAR product without β‐CD shows similar morphology like a product with β‐CD, but the particles show a greater inclination to adhesion. The results were obtained by electron microscopic study.