Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha
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The root extracts of Onosma leptanhtha were evaluated for their anti-iflammatory and cytotoxic activities. The cyclohexane extract, which appeared as the most active in both assays, has been further subjected to bioassay-directed fractionation to afford the naphthazarine derivatives: beta,beta-dimethylacrylshikonin (1), isovalerylshikonin (2) and acetylshikonin (3). The evaluation of the anti-inflammatory activity was performed on carrageenan-induced rat paw edema test. All the tested compounds proved to be active, while compound 3 showed the best anti-inflammatory effect. In addition, the cytotoxic activity of the extracts and isolated compounds, was also assayed against L1210 murine lymphoblastic leukemia cell line, and human fibrosarcoma HT-1080 cells. Compound I exhibited remarkable cytotoxic activity (390nM for L1210 cells), which is superior to that of shikonin, which was used as control.
Keywords:Onosma leptantha / naphthazarines / shikonin-derivatives / anti-inflammatory activity / cytotoxicity
Source:Phytomedicine, 2006, 13, 4, 290-294
- Elsevier Gmbh, Urban & Fischer Verlag, Jena