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dc.creatorĐelić, N
dc.creatorPotparević, Biljana
dc.creatorBajić, Vladan
dc.creatorĐelić, D
dc.date.accessioned2019-09-02T11:07:42Z
dc.date.available2019-09-02T11:07:42Z
dc.date.issued2006
dc.identifier.issn1383-5718
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/851
dc.description.abstractThyroid hormones enhance the metabolic rate and the aerobic metabolism favoring oxidative stress, which is accompanied by induction of damage to cellular macromolecules including the DNA. The aim of the present study was to investigate the ability of thyroxine to induce sister chromatid exchange and micronuclei, and to modulate cell-cycle kinetics in cultured human lymphocytes. Eight experimental concentrations of thyroxine were used, ranging from 2 x 10(-9) to 0.5 x 10(-4) M. Treatment with thyroxine increased the frequency of SCE per cell at the higher concentrations (1.5 x 10(-6), 0.5 10(-5), 1.5 x 10(-5) and 0.5 x 10(-4) M). On the other hand, there were no significant aneugenic and/or clastogenic effects observed in the cytokinesis-block micronucleus assay. The results show that thyroxine acted as a relatively weak clastogen compared with the positive control N-methyl-N '-nitro-N-nitrosoguanidine (MNNG). In addition to the genotoxic effects, two high concentrations of thyroxine decreased the mitotic index and caused cell-cycle delay. In conclusion, thyroxine exhibited weak clastogenic effects only at high concentrations. Therefore, effects in humans might appear in cases of acute thyroxine overdose.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143018/RS//
dc.rightsrestrictedAccess
dc.sourceMutation Research - Genetic Toxicology and Environmental Mutagenesis
dc.subjectthyroxineen
dc.subjectsister chromatid exchangeen
dc.subjectmicronucleien
dc.subjectlymphocytesen
dc.titleSister chromatid exchange and micronuclei in human peripheral blood lymphocytes treated with thyroxine in vitroen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПотпаревић, Биљана; Ђелић, Д; Ђелић, Н; Бајић, Владан;
dc.citation.volume604
dc.citation.issue1-2
dc.citation.spage1
dc.citation.epage7
dc.citation.other604(1-2): 1-7
dc.citation.rankM22
dc.identifier.wos000236994700001
dc.identifier.doi10.1016/j.mrgentox.2005.11.013
dc.identifier.pmid16513411
dc.identifier.scopus2-s2.0-33645976774
dc.identifier.rcubconv_1703
dc.type.versionpublishedVersion


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