Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?

2006
Authors
Vucković, STomić, M
Stepanović-Petrović, Radica

Ugrešić, Nenad
Prostran, Milica

Bošković, B
Article (Published version)
Metadata
Show full item recordAbstract
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
Keywords:
local carbamazepine / inflammatory mechanical hyperalgesia / adenosine A(1) receptorSource:
Journal of Pharmacological Sciences, 2006, 100, 4, 310-314Publisher:
- Japanese Pharmacological Soc, Kyoto
DOI: 10.1254/jphs.SCE05003X
ISSN: 1347-8613
PubMed: 16575152
WoS: 000237098300009
Scopus: 2-s2.0-33645845731
Collections
Institution/Community
PharmacyTY - JOUR AU - Vucković, S AU - Tomić, M AU - Stepanović-Petrović, Radica AU - Ugrešić, Nenad AU - Prostran, Milica AU - Bošković, B PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/853 AB - This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors. PB - Japanese Pharmacological Soc, Kyoto T2 - Journal of Pharmacological Sciences T1 - Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine? VL - 100 IS - 4 SP - 310 EP - 314 DO - 10.1254/jphs.SCE05003X ER -
@article{ author = "Vucković, S and Tomić, M and Stepanović-Petrović, Radica and Ugrešić, Nenad and Prostran, Milica and Bošković, B", year = "2006", abstract = "This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.", publisher = "Japanese Pharmacological Soc, Kyoto", journal = "Journal of Pharmacological Sciences", title = "Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?", volume = "100", number = "4", pages = "310-314", doi = "10.1254/jphs.SCE05003X" }
Vucković, S., Tomić, M., Stepanović-Petrović, R., Ugrešić, N., Prostran, M.,& Bošković, B.. (2006). Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. in Journal of Pharmacological Sciences Japanese Pharmacological Soc, Kyoto., 100(4), 310-314. https://doi.org/10.1254/jphs.SCE05003X
Vucković S, Tomić M, Stepanović-Petrović R, Ugrešić N, Prostran M, Bošković B. Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. in Journal of Pharmacological Sciences. 2006;100(4):310-314. doi:10.1254/jphs.SCE05003X .
Vucković, S, Tomić, M, Stepanović-Petrović, Radica, Ugrešić, Nenad, Prostran, Milica, Bošković, B, "Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?" in Journal of Pharmacological Sciences, 100, no. 4 (2006):310-314, https://doi.org/10.1254/jphs.SCE05003X . .