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Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?

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2006
851.pdf (358.0Kb)
Authors
Vucković, S
Tomić, M
Stepanović-Petrović, Radica
Ugrešić, Nenad
Prostran, Milica
Bošković, B
Article (Published version)
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Abstract
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
Keywords:
local carbamazepine / inflammatory mechanical hyperalgesia / adenosine A(1) receptor
Source:
Journal of Pharmacological Sciences, 2006, 100, 4, 310-314
Publisher:
  • Japanese Pharmacological Soc, Kyoto

DOI: 10.1254/jphs.SCE05003X

ISSN: 1347-8613

PubMed: 16575152

WoS: 000237098300009

Scopus: 2-s2.0-33645845731
[ Google Scholar ]
16
18
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/853
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vucković, S
AU  - Tomić, M
AU  - Stepanović-Petrović, Radica
AU  - Ugrešić, Nenad
AU  - Prostran, Milica
AU  - Bošković, B
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/853
AB  - This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
PB  - Japanese Pharmacological Soc, Kyoto
T2  - Journal of Pharmacological Sciences
T1  - Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
VL  - 100
IS  - 4
SP  - 310
EP  - 314
DO  - 10.1254/jphs.SCE05003X
ER  - 
@article{
author = "Vucković, S and Tomić, M and Stepanović-Petrović, Radica and Ugrešić, Nenad and Prostran, Milica and Bošković, B",
year = "2006",
abstract = "This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?",
volume = "100",
number = "4",
pages = "310-314",
doi = "10.1254/jphs.SCE05003X"
}
Vucković, S., Tomić, M., Stepanović-Petrović, R., Ugrešić, N., Prostran, M.,& Bošković, B.. (2006). Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 100(4), 310-314.
https://doi.org/10.1254/jphs.SCE05003X
Vucković S, Tomić M, Stepanović-Petrović R, Ugrešić N, Prostran M, Bošković B. Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. in Journal of Pharmacological Sciences. 2006;100(4):310-314.
doi:10.1254/jphs.SCE05003X .
Vucković, S, Tomić, M, Stepanović-Petrović, Radica, Ugrešić, Nenad, Prostran, Milica, Bošković, B, "Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?" in Journal of Pharmacological Sciences, 100, no. 4 (2006):310-314,
https://doi.org/10.1254/jphs.SCE05003X . .

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