This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
Keywords:
local carbamazepine / inflammatory mechanical hyperalgesia / adenosine A(1) receptor
Source:
Journal of Pharmacological Sciences, 2006, 100, 4, 310-314
TY - JOUR
AU - Vucković, S
AU - Tomić, M
AU - Stepanović-Petrović, Radica
AU - Ugrešić, Nenad
AU - Prostran, Milica
AU - Bošković, B
PY - 2006
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/853
AB - This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
PB - Japanese Pharmacological Soc, Kyoto
T2 - Journal of Pharmacological Sciences
T1 - Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
VL - 100
IS - 4
SP - 310
EP - 314
DO - 10.1254/jphs.SCE05003X
ER -
@article{
author = "Vucković, S and Tomić, M and Stepanović-Petrović, Radica and Ugrešić, Nenad and Prostran, Milica and Bošković, B",
year = "2006",
abstract = "This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?",
volume = "100",
number = "4",
pages = "310-314",
doi = "10.1254/jphs.SCE05003X"
}
Vucković, S., Tomić, M., Stepanović-Petrović, R., Ugrešić, N., Prostran, M.,& Bošković, B.. (2006). Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 100(4), 310-314.
https://doi.org/10.1254/jphs.SCE05003X
Vucković S, Tomić M, Stepanović-Petrović R, Ugrešić N, Prostran M, Bošković B. Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?. in Journal of Pharmacological Sciences. 2006;100(4):310-314.
doi:10.1254/jphs.SCE05003X .
Vucković, S, Tomić, M, Stepanović-Petrović, Radica, Ugrešić, Nenad, Prostran, Milica, Bošković, B, "Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?" in Journal of Pharmacological Sciences, 100, no. 4 (2006):310-314,
https://doi.org/10.1254/jphs.SCE05003X . .
