Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?

2006
Authors
Vucković, STomić, M
Stepanović-Petrović, Radica

Ugrešić, Nenad
Prostran, Milica

Bošković, B
Article (Published version)
Metadata
Show full item recordAbstract
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.
Keywords:
local carbamazepine / inflammatory mechanical hyperalgesia / adenosine A(1) receptorSource:
Journal of Pharmacological Sciences, 2006, 100, 4, 310-314Publisher:
- Japanese Pharmacological Soc, Kyoto
DOI: 10.1254/jphs.SCE05003X
ISSN: 1347-8613
PubMed: 16575152