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dc.creatorVucković, S
dc.creatorTomić, M
dc.creatorStepanović-Petrović, Radica
dc.creatorUgrešić, Nenad
dc.creatorProstran, Milica
dc.creatorBošković, B
dc.date.accessioned2019-09-02T11:07:46Z
dc.date.available2019-09-02T11:07:46Z
dc.date.issued2006
dc.identifier.issn1347-8613
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/853
dc.description.abstractThis study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10-30 nmol/paw), a selective adenosine A(1)-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A(1) receptors.en
dc.publisherJapanese Pharmacological Soc, Kyoto
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Pharmacological Sciences
dc.subjectlocal carbamazepineen
dc.subjectinflammatory mechanical hyperalgesiaen
dc.subjectadenosine A(1) receptoren
dc.titlePeripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?en
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСтепановић-Петровић, Радица; Вуцковић, С; Угрешић, Ненад; Простран, Милица; Томић, М; Бошковић, Б;
dc.citation.volume100
dc.citation.issue4
dc.citation.spage310
dc.citation.epage314
dc.citation.other100(4): 310-314
dc.citation.rankM22
dc.identifier.wos000237098300009
dc.identifier.doi10.1254/jphs.SCE05003X
dc.identifier.pmid16575152
dc.identifier.scopus2-s2.0-33645845731
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/2219/851.pdf
dc.identifier.rcubconv_1704
dc.type.versionpublishedVersion


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