Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors
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Tomić, Maja
Vučković, Sonja M.
Stepanović-Petrović, Radica

Ugrešić, Nenad
Prostran, Milica

Bošković, Bogdan
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In this study we determined whether oxcarbazepine (OXC) could produce local peripheral antinociceptive effects in a rat model of inflammatory hyperalgesia, and whether adenosine receptors were involved. When coadministered with the pro-inflammatory compound concanavalin A, OXC (1000-3000 nmol/paw) caused a significant dose- and time-dependent anti-hyperalgesia. Caffeine (1000-1500 nmol/paw), a nonselective adenosine receptor antagonist, as well as 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) (10-30 nmol/paw), a selective A, receptor antagonist, coadministered with OXC, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results indicate that OXC produces local peripheral anti-hyperalgesic effects, which is mediated via peripheral A, receptors.
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Pharmazie, 2006, 61, 6, 566-568Publisher:
- Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn
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PharmacyTY - JOUR AU - Tomić, Maja AU - Vučković, Sonja M. AU - Stepanović-Petrović, Radica AU - Ugrešić, Nenad AU - Prostran, Milica AU - Bošković, Bogdan PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/858 AB - In this study we determined whether oxcarbazepine (OXC) could produce local peripheral antinociceptive effects in a rat model of inflammatory hyperalgesia, and whether adenosine receptors were involved. When coadministered with the pro-inflammatory compound concanavalin A, OXC (1000-3000 nmol/paw) caused a significant dose- and time-dependent anti-hyperalgesia. Caffeine (1000-1500 nmol/paw), a nonselective adenosine receptor antagonist, as well as 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) (10-30 nmol/paw), a selective A, receptor antagonist, coadministered with OXC, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results indicate that OXC produces local peripheral anti-hyperalgesic effects, which is mediated via peripheral A, receptors. PB - Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn T2 - Pharmazie T1 - Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors VL - 61 IS - 6 SP - 566 EP - 568 UR - https://hdl.handle.net/21.15107/rcub_farfar_858 ER -
@article{ author = "Tomić, Maja and Vučković, Sonja M. and Stepanović-Petrović, Radica and Ugrešić, Nenad and Prostran, Milica and Bošković, Bogdan", year = "2006", abstract = "In this study we determined whether oxcarbazepine (OXC) could produce local peripheral antinociceptive effects in a rat model of inflammatory hyperalgesia, and whether adenosine receptors were involved. When coadministered with the pro-inflammatory compound concanavalin A, OXC (1000-3000 nmol/paw) caused a significant dose- and time-dependent anti-hyperalgesia. Caffeine (1000-1500 nmol/paw), a nonselective adenosine receptor antagonist, as well as 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) (10-30 nmol/paw), a selective A, receptor antagonist, coadministered with OXC, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results indicate that OXC produces local peripheral anti-hyperalgesic effects, which is mediated via peripheral A, receptors.", publisher = "Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn", journal = "Pharmazie", title = "Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors", volume = "61", number = "6", pages = "566-568", url = "https://hdl.handle.net/21.15107/rcub_farfar_858" }
Tomić, M., Vučković, S. M., Stepanović-Petrović, R., Ugrešić, N., Prostran, M.,& Bošković, B.. (2006). Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors. in Pharmazie Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn., 61(6), 566-568. https://hdl.handle.net/21.15107/rcub_farfar_858
Tomić M, Vučković SM, Stepanović-Petrović R, Ugrešić N, Prostran M, Bošković B. Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors. in Pharmazie. 2006;61(6):566-568. https://hdl.handle.net/21.15107/rcub_farfar_858 .
Tomić, Maja, Vučković, Sonja M., Stepanović-Petrović, Radica, Ugrešić, Nenad, Prostran, Milica, Bošković, Bogdan, "Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors" in Pharmazie, 61, no. 6 (2006):566-568, https://hdl.handle.net/21.15107/rcub_farfar_858 .