Association of C-reactive protein with the presence and extent of angiographically verified coronary artery disease

2006
Authors
Memon, Lidija
Spasojević-Kalimanovska, Vesna

Bogavac-Stanojević, Nataša

Kalimanovska-Oštrić, Dimitra
Jelić-Ivanović, Zorana

Spasić, Slavica
Topić, Aleksandra

Article (Published version)

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Prospective studies have demonstrated that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and fibrinogen, predict future cardiovascular disease risk. However, the association between the hsCRP and fibrinogen levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. The aim of our case-control study was to assess the association of inflammatory markers with the occurrence and extent of CAD. Serum hsCRP and plasma fibrinogen levels were measured in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed (>= 50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease. The hsCRP and fibrinogen levels were significantly higher in patients than in controls (p lt 0.001). Although the hsCRP and fibrinogen levels tended to i...ncrease with the number of stenotic vessels, the differences were only significant for hsCRP (p lt 0.01). Regression analysis indicated hsCRP as an independent predictor for the presence (OR = 3.573, p lt 0.05) and extent of CAD (beta = 1.095, p lt 0.05). In conclusion, the present study is the first report concerning the frequency distribution of hsCRP in Serbian healthy subjects and CAD patients. We have shown that elevated levels of hsCRP are associated with the presence and extent of CAD.-atherosclerosis; inflammation; fibrinogen; hsCRP; coronary artery disease
Keywords:
atherosclerosis / inflammation / fibrinogen / hsCRP / coronary artery diseaseSource:
Toxicological and Environmental Chemistry, 2006, 209, 3, 197-206Publisher:
- Tohoku Univ Medical Press, Sendai
DOI: 10.1620/tjem.209.197
ISSN: 0040-8727
PubMed: 16778366
WoS: 000238210800004
Scopus: 2-s2.0-33745190255
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Institution/Community
PharmacyTY - JOUR AU - Memon, Lidija AU - Spasojević-Kalimanovska, Vesna AU - Bogavac-Stanojević, Nataša AU - Kalimanovska-Oštrić, Dimitra AU - Jelić-Ivanović, Zorana AU - Spasić, Slavica AU - Topić, Aleksandra PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/859 AB - Prospective studies have demonstrated that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and fibrinogen, predict future cardiovascular disease risk. However, the association between the hsCRP and fibrinogen levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. The aim of our case-control study was to assess the association of inflammatory markers with the occurrence and extent of CAD. Serum hsCRP and plasma fibrinogen levels were measured in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed (>= 50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease. The hsCRP and fibrinogen levels were significantly higher in patients than in controls (p lt 0.001). Although the hsCRP and fibrinogen levels tended to increase with the number of stenotic vessels, the differences were only significant for hsCRP (p lt 0.01). Regression analysis indicated hsCRP as an independent predictor for the presence (OR = 3.573, p lt 0.05) and extent of CAD (beta = 1.095, p lt 0.05). In conclusion, the present study is the first report concerning the frequency distribution of hsCRP in Serbian healthy subjects and CAD patients. We have shown that elevated levels of hsCRP are associated with the presence and extent of CAD.-atherosclerosis; inflammation; fibrinogen; hsCRP; coronary artery disease PB - Tohoku Univ Medical Press, Sendai T2 - Toxicological and Environmental Chemistry T1 - Association of C-reactive protein with the presence and extent of angiographically verified coronary artery disease VL - 209 IS - 3 SP - 197 EP - 206 DO - 10.1620/tjem.209.197 ER -
@article{ author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana and Spasić, Slavica and Topić, Aleksandra", year = "2006", abstract = "Prospective studies have demonstrated that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and fibrinogen, predict future cardiovascular disease risk. However, the association between the hsCRP and fibrinogen levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. The aim of our case-control study was to assess the association of inflammatory markers with the occurrence and extent of CAD. Serum hsCRP and plasma fibrinogen levels were measured in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed (>= 50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease. The hsCRP and fibrinogen levels were significantly higher in patients than in controls (p lt 0.001). Although the hsCRP and fibrinogen levels tended to increase with the number of stenotic vessels, the differences were only significant for hsCRP (p lt 0.01). Regression analysis indicated hsCRP as an independent predictor for the presence (OR = 3.573, p lt 0.05) and extent of CAD (beta = 1.095, p lt 0.05). In conclusion, the present study is the first report concerning the frequency distribution of hsCRP in Serbian healthy subjects and CAD patients. We have shown that elevated levels of hsCRP are associated with the presence and extent of CAD.-atherosclerosis; inflammation; fibrinogen; hsCRP; coronary artery disease", publisher = "Tohoku Univ Medical Press, Sendai", journal = "Toxicological and Environmental Chemistry", title = "Association of C-reactive protein with the presence and extent of angiographically verified coronary artery disease", volume = "209", number = "3", pages = "197-206", doi = "10.1620/tjem.209.197" }
Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Jelić-Ivanović, Z., Spasić, S.,& Topić, A.. (2006). Association of C-reactive protein with the presence and extent of angiographically verified coronary artery disease. in Toxicological and Environmental Chemistry Tohoku Univ Medical Press, Sendai., 209(3), 197-206. https://doi.org/10.1620/tjem.209.197
Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Jelić-Ivanović Z, Spasić S, Topić A. Association of C-reactive protein with the presence and extent of angiographically verified coronary artery disease. in Toxicological and Environmental Chemistry. 2006;209(3):197-206. doi:10.1620/tjem.209.197 .
Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, Spasić, Slavica, Topić, Aleksandra, "Association of C-reactive protein with the presence and extent of angiographically verified coronary artery disease" in Toxicological and Environmental Chemistry, 209, no. 3 (2006):197-206, https://doi.org/10.1620/tjem.209.197 . .