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dc.creatorMemon, Lidija
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorBogavac-Stanojević, Nataša
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasić, Slavica
dc.creatorTopić, Aleksandra
dc.date.accessioned2019-09-02T11:07:54Z
dc.date.available2019-09-02T11:07:54Z
dc.date.issued2006
dc.identifier.issn0040-8727
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/859
dc.description.abstractProspective studies have demonstrated that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and fibrinogen, predict future cardiovascular disease risk. However, the association between the hsCRP and fibrinogen levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. The aim of our case-control study was to assess the association of inflammatory markers with the occurrence and extent of CAD. Serum hsCRP and plasma fibrinogen levels were measured in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed (>= 50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease. The hsCRP and fibrinogen levels were significantly higher in patients than in controls (p lt 0.001). Although the hsCRP and fibrinogen levels tended to increase with the number of stenotic vessels, the differences were only significant for hsCRP (p lt 0.01). Regression analysis indicated hsCRP as an independent predictor for the presence (OR = 3.573, p lt 0.05) and extent of CAD (beta = 1.095, p lt 0.05). In conclusion, the present study is the first report concerning the frequency distribution of hsCRP in Serbian healthy subjects and CAD patients. We have shown that elevated levels of hsCRP are associated with the presence and extent of CAD.-atherosclerosis; inflammation; fibrinogen; hsCRP; coronary artery diseaseen
dc.publisherTohoku Univ Medical Press, Sendai
dc.rightsopenAccess
dc.sourceToxicological and Environmental Chemistry
dc.subjectatherosclerosisen
dc.subjectinflammationen
dc.subjectfibrinogenen
dc.subjecthsCRPen
dc.subjectcoronary artery diseaseen
dc.titleAssociation of C-reactive protein with the presence and extent of angiographically verified coronary artery diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасојевић-Калимановска, Весна; Мемон, Лидија; Калимановска-Оштрић, Димитра; Богавац-Станојевић, Наташа; Спасић, Славица; Топић, Aлександра; Јелић-Ивановић, Зорана;
dc.citation.volume209
dc.citation.issue3
dc.citation.spage197
dc.citation.epage206
dc.citation.other209(3): 197-206
dc.citation.rankM22
dc.identifier.wos000238210800004
dc.identifier.doi10.1620/tjem.209.197
dc.identifier.pmid16778366
dc.identifier.scopus2-s2.0-33745190255
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/2223/857.pdf
dc.identifier.rcubconv_1716
dc.type.versionpublishedVersion


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