FarFaR - Farmaceutski fakultet, repozitorijum
Univerzitet u Beogradu, Farmaceutski fakultet
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  •   FarFaR - Farmaceutski fakultet, repozitorijum
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Pregled rada
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Determination of paracetamol in pure and pharmaceutical dosage forms by pulse perturbation technique

Samo za registrovane korisnike
2006
Autori
Pejić, Nataša
Kolar-Anić, Ljiljana
Anić, Slobodan
Stanisavljev, Dragomir
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
A new procedure for kinetic determination of paracetamol in pharmaceuticals is proposed. The method is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system being in a stable non-equilibrium stationary state close to the bifurcation point. In the case considered as the matrix system, the Bray-Liebhafsky oscillatory reaction is used. The response of the matrix system to the perturbations by different concentrations of paracetamol is followed by a Pt-electrode. Proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of added paracetamol amounts. It is obtained in optimized experimental conditions for variable amounts of paracetamol in the range 0.0085 and 1.5 mu mol. The sensitivity and precision of proposed method were quite good (0.0027 mu mol as the limit of detection and 2.4% as R.S.D.). Some aspects of possible chemical interactions between paracetamol and matrix are discussed. Appl...icability of the proposed method to the direct determination of paracetamol in pharmaceutical formulations was demonstrated.

Ključne reči:
Bray-Liebhafsky oscillatory reaction / paracetamol / perturbations / pharmaceutical preparations
Izvor:
Journal of Pharmaceutical and Biomedical Analysis, 2006, 41, 2, 610-615
Izdavač:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/j.jpba.2005.11.043

ISSN: 0731-7085

PubMed: 16413730

WoS: 000237705700040

Scopus: 2-s2.0-33645969630
[ Google Scholar ]
33
32
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/861
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

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