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dc.creatorPejić, Nataša
dc.creatorKolar-Anić, Ljiljana
dc.creatorAnić, Slobodan
dc.creatorStanisavljev, Dragomir
dc.date.accessioned2019-09-02T11:07:56Z
dc.date.available2019-09-02T11:07:56Z
dc.date.issued2006
dc.identifier.issn0731-7085
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/861
dc.description.abstractA new procedure for kinetic determination of paracetamol in pharmaceuticals is proposed. The method is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system being in a stable non-equilibrium stationary state close to the bifurcation point. In the case considered as the matrix system, the Bray-Liebhafsky oscillatory reaction is used. The response of the matrix system to the perturbations by different concentrations of paracetamol is followed by a Pt-electrode. Proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of added paracetamol amounts. It is obtained in optimized experimental conditions for variable amounts of paracetamol in the range 0.0085 and 1.5 mu mol. The sensitivity and precision of proposed method were quite good (0.0027 mu mol as the limit of detection and 2.4% as R.S.D.). Some aspects of possible chemical interactions between paracetamol and matrix are discussed. Applicability of the proposed method to the direct determination of paracetamol in pharmaceutical formulations was demonstrated.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectBray-Liebhafsky oscillatory reactionen
dc.subjectparacetamolen
dc.subjectperturbationsen
dc.subjectpharmaceutical preparationsen
dc.titleDetermination of paracetamol in pure and pharmaceutical dosage forms by pulse perturbation techniqueen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПејић, Наташа; Станисављев, Драгомир; Колар-Aнић, Љиљана; Aнић, Слободан;
dc.citation.volume41
dc.citation.issue2
dc.citation.spage610
dc.citation.epage615
dc.citation.other41(2): 610-615
dc.citation.rankM22
dc.identifier.wos000237705700040
dc.identifier.doi10.1016/j.jpba.2005.11.043
dc.identifier.pmid16413730
dc.identifier.scopus2-s2.0-33645969630
dc.identifier.rcubconv_1711
dc.type.versionpublishedVersion


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