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Kiselinsko-bazne ravnoteže 2,4-dijod-6-metilfenilkarbamoilmetil iminodisirćetne kiseline i obeležavanje tehnecijumom-99m

dc.creatorBrborić, Jasmina
dc.creatorJovanović, Mirjana S.
dc.creatorPopović, Gordana
dc.creatorKapetanović, Vera
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:08:18Z
dc.date.available2019-09-02T11:08:18Z
dc.date.issued2006
dc.identifier.issn0352-5139
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/875
dc.description.abstractThe acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 and pK4 = 10.9 ± 0.1. The determinations were performed at 25 ºC and an ionic strength of 0.1 mol/dm3 (NaCl). The acidity constants (pK1 = 1.3 ± 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 ºC and an ionic strength 1 mol/dm3 (HCl, NaCl). DIIODIDA was labeled with technetium-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity (>98 %).en
dc.description.abstractIspitane su kiselinsko-bazne ravnoteže novog hepatobilijarnog agensa, 2,4-dijod- 6-metilfenilkarbamoilmetil iminodisirćetne kiseline. Kiselinske konstante koje odgovaraju drugoj karboksilnoj grupi, amino i amidnoj grupi određene su potenciometrijski: pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 I pK4 = 10.9 ± 0.1. Određivanja su izvedena na 25 ºC i pri konstantnoj jonskoj sili 0,1 mol/dm3 (NaCl). Kiselinska konstanta prve karboksilne grupe (pK1 = 1,3_0,4) određena je indirektno na osnovu ravnotežnih konstanti određenih u heterogenom sistemu, na 25 ºC i jonskoj sili 1 mol/dm3 (HCl, NaCl). DIIODIDA je obeležena tehnecijumom-99m i ispitan je uticaj pH na prinos obeležavanja. Utvrđeno je da se obeležavanjem u pH opsegu 5,5-6,5 dobija radiofarmaceutik visoke radiohemijske čistoće (> 98 %).sr
dc.publisherSrpsko hemijsko društvo, Beograd
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectiminodiacetic acid analoguesen
dc.subjectacidity constantsen
dc.subjecthepatobiliary agenten
dc.subjecttechnetium-99men
dc.titleAcid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99men
dc.titleKiselinsko-bazne ravnoteže 2,4-dijod-6-metilfenilkarbamoilmetil iminodisirćetne kiseline i obeležavanje tehnecijumom-99msr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЈовановић, Мирјана С.; Брборић, Јасмина; Капетановић, Вера; Владимиров, Соте; Поповић, Гордана; Киселинско-базне равнотеже 2,4-дијод-6-метилфенилкарбамоилметил иминодисирћетне киселине и обележавање технецијумом-99м; Киселинско-базне равнотеже 2,4-дијод-6-метилфенилкарбамоилметил иминодисирћетне киселине и обележавање технецијумом-99м;
dc.citation.volume71
dc.citation.issue1
dc.citation.spage55
dc.citation.epage65
dc.citation.other71(1): 55-65
dc.citation.rankM23
dc.identifier.wos000235562500006
dc.identifier.doi10.2298/JSC0601055B
dc.identifier.scopus2-s2.0-33644966489
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2235/873.pdf
dc.identifier.rcubconv_768
dc.type.versionpublishedVersion


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