Приказ основних података о документу
Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
Kiselinsko-bazne ravnoteže 2,4-dijod-6-metilfenilkarbamoilmetil iminodisirćetne kiseline i obeležavanje tehnecijumom-99m
dc.creator | Brborić, Jasmina | |
dc.creator | Jovanović, Mirjana S. | |
dc.creator | Popović, Gordana | |
dc.creator | Kapetanović, Vera | |
dc.creator | Vladimirov, Sote | |
dc.date.accessioned | 2019-09-02T11:08:18Z | |
dc.date.available | 2019-09-02T11:08:18Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/875 | |
dc.description.abstract | The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 and pK4 = 10.9 ± 0.1. The determinations were performed at 25 ºC and an ionic strength of 0.1 mol/dm3 (NaCl). The acidity constants (pK1 = 1.3 ± 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 ºC and an ionic strength 1 mol/dm3 (HCl, NaCl). DIIODIDA was labeled with technetium-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity (>98 %). | en |
dc.description.abstract | Ispitane su kiselinsko-bazne ravnoteže novog hepatobilijarnog agensa, 2,4-dijod- 6-metilfenilkarbamoilmetil iminodisirćetne kiseline. Kiselinske konstante koje odgovaraju drugoj karboksilnoj grupi, amino i amidnoj grupi određene su potenciometrijski: pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 I pK4 = 10.9 ± 0.1. Određivanja su izvedena na 25 ºC i pri konstantnoj jonskoj sili 0,1 mol/dm3 (NaCl). Kiselinska konstanta prve karboksilne grupe (pK1 = 1,3_0,4) određena je indirektno na osnovu ravnotežnih konstanti određenih u heterogenom sistemu, na 25 ºC i jonskoj sili 1 mol/dm3 (HCl, NaCl). DIIODIDA je obeležena tehnecijumom-99m i ispitan je uticaj pH na prinos obeležavanja. Utvrđeno je da se obeležavanjem u pH opsegu 5,5-6,5 dobija radiofarmaceutik visoke radiohemijske čistoće (> 98 %). | sr |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | iminodiacetic acid analogues | en |
dc.subject | acidity constants | en |
dc.subject | hepatobiliary agent | en |
dc.subject | technetium-99m | en |
dc.title | Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m | en |
dc.title | Kiselinsko-bazne ravnoteže 2,4-dijod-6-metilfenilkarbamoilmetil iminodisirćetne kiseline i obeležavanje tehnecijumom-99m | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Јовановић, Мирјана С.; Брборић, Јасмина; Капетановић, Вера; Владимиров, Соте; Поповић, Гордана; Киселинско-базне равнотеже 2,4-дијод-6-метилфенилкарбамоилметил иминодисирћетне киселине и обележавање технецијумом-99м; Киселинско-базне равнотеже 2,4-дијод-6-метилфенилкарбамоилметил иминодисирћетне киселине и обележавање технецијумом-99м; | |
dc.citation.volume | 71 | |
dc.citation.issue | 1 | |
dc.citation.spage | 55 | |
dc.citation.epage | 65 | |
dc.citation.other | 71(1): 55-65 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000235562500006 | |
dc.identifier.doi | 10.2298/JSC0601055B | |
dc.identifier.scopus | 2-s2.0-33644966489 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2235/873.pdf | |
dc.type.version | publishedVersion |