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Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole
dc.creator | Ninković, Milica | |
dc.creator | Maličević, Živorad | |
dc.creator | Jelenković, Ankica V. | |
dc.creator | Jovanović, D.M | |
dc.creator | Đukić, Mirjana | |
dc.creator | Vasiljević, Ivana | |
dc.date.accessioned | 2019-09-02T11:08:35Z | |
dc.date.available | 2019-09-02T11:08:35Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0231-424X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/887 | |
dc.description.abstract | As a part of blood-brain barrier, brain capillaries participate in pathophysiological events during systemic inflammation. We investigated the effects of 7-nitroindazole (7-NI), selective neuronal nitric oxide synthase (NOS) inhibitor, to oxidative status (OS) of brain capillaries. Adult Wistar rats were randomized at groups: control group (CG) (sham operated), sepsis group (GS) (cecal ligation and perforation with inoculation of Escherichia coli (ATCC 25922), 7-NI group (G7-NI), (30 mg/ kg b/w i. p.) and 7-NI + sepsis group (G7-NIS), (7-NI was applied 30 minutes before operation). Lipid peroxidation index (LPI), nitrite concentration, superoxide dismutase (SOD) activity and superoxide anion (O2*-) content were determined 3, 6, 24 and 48 hour in each group. Cerebral capillaries were separated from non-vascular brain tissue using sucrose gradient. Compared to controls, LPI, nitrite and O2*- increased at SG. In the G7-NIS, LPI reached control values at the 24th and 48th hour, while nitrite were decreased at the 3rd and 24th hour, compared to controls. In the same group, O2*- decreased at the 3rd, 6th and 24th hour, although SOD showed variable activity. The systematic nNOS inhibition with 7-NI forces OS on early terms of sepsis, but lately it contributes to the normalization of OS in cerebral capillaries. | en |
dc.rights | restrictedAccess | |
dc.source | Acta Physiologica Hungarica | |
dc.subject | 7-nitroindazole | en |
dc.subject | Brain | en |
dc.subject | Capillaries | en |
dc.subject | Oxidative stress | en |
dc.subject | Rat | en |
dc.subject | Sepsis | en |
dc.title | Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Нинковић, Милица; Васиљевић, Ивана; Ђукић, Мирјана; Маличевић, Живорад; Јеленковић, Aнкица В.; Јовановић, Д.М; | |
dc.citation.volume | 93 | |
dc.citation.issue | 4 | |
dc.citation.spage | 315 | |
dc.citation.epage | 323 | |
dc.citation.other | 93(4): 315-323 | |
dc.identifier.doi | 10.1556/APhysiol.93.2006.4.7 | |
dc.identifier.scopus | 2-s2.0-33845873915 | |
dc.type.version | publishedVersion |
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