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dc.creatorStarcević, D
dc.creatorJelić-Ivanović, Zorana
dc.creatorKalimanovska, Vesna
dc.date.accessioned2019-09-02T10:48:10Z
dc.date.available2019-09-02T10:48:10Z
dc.date.issued1991
dc.identifier.issn0004-5632
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/88
dc.description.abstractPlasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. Cl-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods were good, with CVs ranging from 3.6 to 5.4%. Plasma C1-INH antigen concentrations were significantly higher in the patients than in healthy controls (P=4.0 x 10-3), as were their C1-INH functional activities (P=3.5 x 10-3). C1-INH activities obtained in the patient plasma samples were in correlation with their antigen concentrations (r = 0.914), showing that C1-INH synthesized in malignant disease was functional. However, the specific activity of the C1-INH (functional activity/antigen concentration ratio) was significantly lower in the patient group as compared with the controls (P=2.1 x 10-6), indicating partial inactivation of plasma C1-INH in malignant diseases. The C1-INH specific activity in patients was inversely proportional to its antigen concentration.en
dc.rightsrestrictedAccess
dc.sourceAnnals of Clinical Biochemistry
dc.subjectChromogenic substrateen
dc.subjectComplementen
dc.subjectRadial immunodiffusionen
dc.titlePlasma C1 inhibitor in malignant diseases: Functional activity versus concentrationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКалимановска, Весна; Старцевић, Д; Јелић-Ивановић, Зорана;
dc.citation.volume28
dc.citation.issue6
dc.citation.spage595
dc.citation.epage598
dc.citation.other28(6): 595-598
dc.identifier.doi10.1177/000456329102800609
dc.identifier.scopus2-s2.0-0025994687
dc.identifier.rcubconv_5544
dc.type.versionpublishedVersion


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