dc.creator | Starcević, D | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Kalimanovska, Vesna | |
dc.date.accessioned | 2019-09-02T10:48:10Z | |
dc.date.available | 2019-09-02T10:48:10Z | |
dc.date.issued | 1991 | |
dc.identifier.issn | 0004-5632 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/88 | |
dc.description.abstract | Plasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. Cl-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods were good, with CVs ranging from 3.6 to 5.4%. Plasma C1-INH antigen concentrations were significantly higher in the patients than in healthy controls (P=4.0 x 10-3), as were their C1-INH functional activities (P=3.5 x 10-3). C1-INH activities obtained in the patient plasma samples were in correlation with their antigen concentrations (r = 0.914), showing that C1-INH synthesized in malignant disease was functional. However, the specific activity of the C1-INH (functional activity/antigen concentration ratio) was significantly lower in the patient group as compared with the controls (P=2.1 x 10-6), indicating partial inactivation of plasma C1-INH in malignant diseases. The C1-INH specific activity in patients was inversely proportional to its antigen concentration. | en |
dc.rights | restrictedAccess | |
dc.source | Annals of Clinical Biochemistry | |
dc.subject | Chromogenic substrate | en |
dc.subject | Complement | en |
dc.subject | Radial immunodiffusion | en |
dc.title | Plasma C1 inhibitor in malignant diseases: Functional activity versus concentration | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Калимановска, Весна; Старцевић, Д; Јелић-Ивановић, Зорана; | |
dc.citation.volume | 28 | |
dc.citation.issue | 6 | |
dc.citation.spage | 595 | |
dc.citation.epage | 598 | |
dc.citation.other | 28(6): 595-598 | |
dc.identifier.doi | 10.1177/000456329102800609 | |
dc.identifier.scopus | 2-s2.0-0025994687 | |
dc.type.version | publishedVersion | |