Приказ основних података о документу
Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles
dc.creator | Cekić, Nebojša | |
dc.creator | Savić, Snežana | |
dc.creator | Milić, Jela | |
dc.creator | Savić, Miroslav | |
dc.creator | Jović, Žarko | |
dc.creator | Malesević, Marjia | |
dc.date.accessioned | 2019-09-02T11:08:41Z | |
dc.date.available | 2019-09-02T11:08:41Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1071-7544 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/890 | |
dc.description.abstract | We aimed to prepare and investigate microparticles with the varying contents of calcium gelling ion, loaded with phenytoin, a standard antiepileptic agent, in its acidic form. Two different methods of alginate-based microparticles preparation were used: with and without treatment with chitosan. Furthermore, two standard procedures, the one-stage and the two-stage, were applied. Microparticle size of 12 one-stage formulations ranged from 466 to 636 m. Both types of formulations, chitosan-treated and nontreated, appeared to be highly loaded with the model drug ( 91-96%). The chitosan-coated alginate-based microparticles prepared by the one-stage procedure exhibited kinetics of phenytoin liberation comparable to a similar sustained release system that had been tested at pH 6.8, as published earlier. As the gel erosion of alginate-based microparticles should be potentiated by the higher pH ( used in the present study at pH 7.4), the most favorable of 12 formulations, with the liberation half-time of about 2 hr, seemed to be eligible for further modifications. Counterintuitively, the applied two-stage procedure did not appear to beneficially affect the dissolution behavior of phenytoin when tested in two formulations, which makes further modifications necessary. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142063/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Drug Delivery | |
dc.subject | alginate-chitosan microparticles | en |
dc.subject | phenytoin | en |
dc.subject | preparation | en |
dc.subject | release behavior | en |
dc.title | Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Савић, Мирослав; Малесевић, Марјиа; Јовић, Жарко; Савић, Снежана; Цекић, Небојша; Милић, Јела; | |
dc.citation.volume | 14 | |
dc.citation.issue | 8 | |
dc.citation.spage | 483 | |
dc.citation.epage | 490 | |
dc.citation.other | 14(8): 483-490 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000251027200001 | |
dc.identifier.doi | 10.1080/10717540701604769 | |
dc.identifier.pmid | 18027177 | |
dc.identifier.scopus | 2-s2.0-36249012569 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2247/888.pdf | |
dc.type.version | publishedVersion |