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dc.creatorCekić, Nebojša
dc.creatorSavić, Snežana
dc.creatorMilić, Jela
dc.creatorSavić, Miroslav
dc.creatorJović, Žarko
dc.creatorMalesević, Marjia
dc.date.accessioned2019-09-02T11:08:41Z
dc.date.available2019-09-02T11:08:41Z
dc.date.issued2007
dc.identifier.issn1071-7544
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/890
dc.description.abstractWe aimed to prepare and investigate microparticles with the varying contents of calcium gelling ion, loaded with phenytoin, a standard antiepileptic agent, in its acidic form. Two different methods of alginate-based microparticles preparation were used: with and without treatment with chitosan. Furthermore, two standard procedures, the one-stage and the two-stage, were applied. Microparticle size of 12 one-stage formulations ranged from 466 to 636 m. Both types of formulations, chitosan-treated and nontreated, appeared to be highly loaded with the model drug ( 91-96%). The chitosan-coated alginate-based microparticles prepared by the one-stage procedure exhibited kinetics of phenytoin liberation comparable to a similar sustained release system that had been tested at pH 6.8, as published earlier. As the gel erosion of alginate-based microparticles should be potentiated by the higher pH ( used in the present study at pH 7.4), the most favorable of 12 formulations, with the liberation half-time of about 2 hr, seemed to be eligible for further modifications. Counterintuitively, the applied two-stage procedure did not appear to beneficially affect the dissolution behavior of phenytoin when tested in two formulations, which makes further modifications necessary.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142063/RS//
dc.rightsopenAccess
dc.sourceDrug Delivery
dc.subjectalginate-chitosan microparticlesen
dc.subjectphenytoinen
dc.subjectpreparationen
dc.subjectrelease behavioren
dc.titlePreparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticlesen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractСавић, Мирослав; Малесевић, Марјиа; Јовић, Жарко; Савић, Снежана; Цекић, Небојша; Милић, Јела;
dc.citation.volume14
dc.citation.issue8
dc.citation.spage483
dc.citation.epage490
dc.citation.other14(8): 483-490
dc.citation.rankM23
dc.identifier.wos000251027200001
dc.identifier.doi10.1080/10717540701604769
dc.identifier.pmid18027177
dc.identifier.scopus2-s2.0-36249012569
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2247/888.pdf
dc.identifier.rcubconv_1929
dc.type.versionpublishedVersion


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