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dc.creatorPejić, Nataša
dc.creatorBlagojević, Slavica
dc.creatorAnić, Slobodan
dc.creatorKolar-Anić, Ljiljana
dc.date.accessioned2019-09-02T11:08:43Z
dc.date.available2019-09-02T11:08:43Z
dc.date.issued2007
dc.identifier.issn1618-2642
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/892
dc.description.abstractA simple and reliable method for the determination of ascorbic acid (AA) is proposed and validated. It is based on potentiometric monitoring of the concentration perturbations of an oscillatory reaction system in a stable nonequilibrium stationary state close to the bifurcation point. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix, to the perturbation by different concentrations of AA, is followed by a Pt electrode. The linear relationship between maximal potential shift and the logarithm of the amount of AA is obtained between 0.01 and 1.0 mu mol. The sensitivity of the proposed method (as the limit of detection) is 0.009 mu mol and the method has excellent sample throughput (30 samples per hour). The procedure was used for AA determination in pharmaceutical formulations and urine. The results are in agreement with those obtained using the official method. Some aspects of the possible mechanism of AA action on the BL oscillating chemical system are discussed.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.rightsrestrictedAccess
dc.sourceAnalytical and Bioanalytical Chemistry
dc.subjectdetermination of ascorbic aciden
dc.subjectperturbation techniqueen
dc.subjectbray-liebhafsky oscillatory reactionen
dc.subjectpharmaceutical dosage formsen
dc.subjecturineen
dc.titleDetermination of ascorbic acid in pharmaceutical dosage forms and urine by means of an oscillatory reaction system using the pulse perturbation techniqueen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПејић, Наташа; Колар-Aнић, Љиљана; Aнић, Слободан; Благојевић, Славица;
dc.citation.volume389
dc.citation.issue6
dc.citation.spage2009
dc.citation.epage2017
dc.citation.other389(6): 2009-2017
dc.citation.rankM21
dc.identifier.wos000251133100032
dc.identifier.doi10.1007/s00216-007-1585-4
dc.identifier.pmid17932659
dc.identifier.scopus2-s2.0-36849083989
dc.identifier.rcubconv_1932
dc.type.versionpublishedVersion


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