Analyte pulse perturbation technique for the determination of 6-O-acetylmorphine in seized street drug samples
Abstract
A pulse perturbation technique was applied to the Bray-Liebhafsky (BL) oscillatory reaction system in a stable nonequilibrium stationary state close to the bifurcation point, to determine micro-quantitatively 6-O-acetylmorphine (6-O-AM). The proposed method, in optimized reaction conditions ([KIO3](0) = 5.9 x 10(-2) M, [H2SO4](0) = 5.5 x 10(-2) M, and [H2O2](0) = 2.0 x 10(-1) M, j(o) = 2.95 x 10(-2) min(-1), and T = 42.9 degrees C), relied on the linear relationship between maximal potential shift, Delta E-m, caused by perturbation, and the logarithm of the amount of 6-O-acetylmorphine. The method had a rather good sample throughput of 40 samples h(-1) with the sensitivity determined to be 0.9 mu g mL(-1) and the precision RSD = 1.8%. The proposed method was successfully applied to the quantitative determination of 6-O-AM in a real seized street drug sample. The obtained result agrees with those obtained by HPLC. There was no interference from structurally related and associated compou...nds, such as papaverin, noscapin, and heroin.
Source:
Bulletin of the Chemical Society of Japan, 2007, 80, 10, 1942-1948Publisher:
- Chemical Soc Japan, Tokyo
DOI: 10.1246/bcsj.80.1942
ISSN: 0009-2673
WoS: 000250698400011
Scopus: 2-s2.0-58149299574
Collections
Institution/Community
PharmacyTY - JOUR AU - Pejić, Nataša AU - Blagojević, Slavica AU - Vukelić, Jana AU - Kolar-Anić, Ljiljana AU - Anić, Slobodan PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/895 AB - A pulse perturbation technique was applied to the Bray-Liebhafsky (BL) oscillatory reaction system in a stable nonequilibrium stationary state close to the bifurcation point, to determine micro-quantitatively 6-O-acetylmorphine (6-O-AM). The proposed method, in optimized reaction conditions ([KIO3](0) = 5.9 x 10(-2) M, [H2SO4](0) = 5.5 x 10(-2) M, and [H2O2](0) = 2.0 x 10(-1) M, j(o) = 2.95 x 10(-2) min(-1), and T = 42.9 degrees C), relied on the linear relationship between maximal potential shift, Delta E-m, caused by perturbation, and the logarithm of the amount of 6-O-acetylmorphine. The method had a rather good sample throughput of 40 samples h(-1) with the sensitivity determined to be 0.9 mu g mL(-1) and the precision RSD = 1.8%. The proposed method was successfully applied to the quantitative determination of 6-O-AM in a real seized street drug sample. The obtained result agrees with those obtained by HPLC. There was no interference from structurally related and associated compounds, such as papaverin, noscapin, and heroin. PB - Chemical Soc Japan, Tokyo T2 - Bulletin of the Chemical Society of Japan T1 - Analyte pulse perturbation technique for the determination of 6-O-acetylmorphine in seized street drug samples VL - 80 IS - 10 SP - 1942 EP - 1948 DO - 10.1246/bcsj.80.1942 ER -
@article{ author = "Pejić, Nataša and Blagojević, Slavica and Vukelić, Jana and Kolar-Anić, Ljiljana and Anić, Slobodan", year = "2007", abstract = "A pulse perturbation technique was applied to the Bray-Liebhafsky (BL) oscillatory reaction system in a stable nonequilibrium stationary state close to the bifurcation point, to determine micro-quantitatively 6-O-acetylmorphine (6-O-AM). The proposed method, in optimized reaction conditions ([KIO3](0) = 5.9 x 10(-2) M, [H2SO4](0) = 5.5 x 10(-2) M, and [H2O2](0) = 2.0 x 10(-1) M, j(o) = 2.95 x 10(-2) min(-1), and T = 42.9 degrees C), relied on the linear relationship between maximal potential shift, Delta E-m, caused by perturbation, and the logarithm of the amount of 6-O-acetylmorphine. The method had a rather good sample throughput of 40 samples h(-1) with the sensitivity determined to be 0.9 mu g mL(-1) and the precision RSD = 1.8%. The proposed method was successfully applied to the quantitative determination of 6-O-AM in a real seized street drug sample. The obtained result agrees with those obtained by HPLC. There was no interference from structurally related and associated compounds, such as papaverin, noscapin, and heroin.", publisher = "Chemical Soc Japan, Tokyo", journal = "Bulletin of the Chemical Society of Japan", title = "Analyte pulse perturbation technique for the determination of 6-O-acetylmorphine in seized street drug samples", volume = "80", number = "10", pages = "1942-1948", doi = "10.1246/bcsj.80.1942" }
Pejić, N., Blagojević, S., Vukelić, J., Kolar-Anić, L.,& Anić, S.. (2007). Analyte pulse perturbation technique for the determination of 6-O-acetylmorphine in seized street drug samples. in Bulletin of the Chemical Society of Japan Chemical Soc Japan, Tokyo., 80(10), 1942-1948. https://doi.org/10.1246/bcsj.80.1942
Pejić N, Blagojević S, Vukelić J, Kolar-Anić L, Anić S. Analyte pulse perturbation technique for the determination of 6-O-acetylmorphine in seized street drug samples. in Bulletin of the Chemical Society of Japan. 2007;80(10):1942-1948. doi:10.1246/bcsj.80.1942 .
Pejić, Nataša, Blagojević, Slavica, Vukelić, Jana, Kolar-Anić, Ljiljana, Anić, Slobodan, "Analyte pulse perturbation technique for the determination of 6-O-acetylmorphine in seized street drug samples" in Bulletin of the Chemical Society of Japan, 80, no. 10 (2007):1942-1948, https://doi.org/10.1246/bcsj.80.1942 . .