Mass spectrometric investigation of 2‐aminopropiophenones and some of their metabolites

Abstract

Complex metabolic mixtures of 2‐aminopropiophenones, obtained both after in vitro and human in vivo metabolism of these compounds, have been investigated using both mass spectrometry and gas chromatography/mass spectrometry. The mass spectrometric fragmentation schemes of the compounds have been proposed and verified. The schemes are based on the characteristic fragments obtained by alpha‐cleavage of these compounds using direct inlet mass spectrometry or gass chromatography/mass spectrometry. these findings were confirmed with chemical ionization mass spectrometry, when quasi‐molecular (MH+) ions were obtained as the highest relative abundane ions for all the compounds investigated, and were used in metabolic investigations of 2‐aminopropiophenones.