Special interest in alternative approach to clinical pharmacokinetic research nowadays, especially in pediatric practice, is concerned on biological fluids obtainable by non- invasive methodology. Saliva and urine are the most interesting fluids in this approach. The possibility of using saliva and urine was investigated and evaluated in theophylline (Th) therapy, both in asthmatic children and adults. The investigation on drug presence in saliva (asthmatic children and adults) and in urine (asthmatic children) during Th therapy, confirmed good correlation between saliva and plasma, and between urine and plasma, and provided reliable basis for the conclusion that both saliva and urine can be used in pharmacokinetic research of The elimination in asthmatic children. Only saliva was investigated in adult patients and it was found that it can be used as alternative biological fluid in pharmacokinetic research, but with less reliability than in children.
Source:
European Journal of Drug Metabolism and Pharmacokinetics, 1991, 513-518
TY - JOUR
AU - Pokrajac, Milena
AU - Agbaba, Danica
AU - Miljković, Branislava
AU - Varagić, V.M.
PY - 1991
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/90
AB - Special interest in alternative approach to clinical pharmacokinetic research nowadays, especially in pediatric practice, is concerned on biological fluids obtainable by non- invasive methodology. Saliva and urine are the most interesting fluids in this approach. The possibility of using saliva and urine was investigated and evaluated in theophylline (Th) therapy, both in asthmatic children and adults. The investigation on drug presence in saliva (asthmatic children and adults) and in urine (asthmatic children) during Th therapy, confirmed good correlation between saliva and plasma, and between urine and plasma, and provided reliable basis for the conclusion that both saliva and urine can be used in pharmacokinetic research of The elimination in asthmatic children. Only saliva was investigated in adult patients and it was found that it can be used as alternative biological fluid in pharmacokinetic research, but with less reliability than in children.
T2 - European Journal of Drug Metabolism and Pharmacokinetics
T1 - When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.
SP - 513
EP - 518
UR - https://hdl.handle.net/21.15107/rcub_farfar_90
ER -
@article{
author = "Pokrajac, Milena and Agbaba, Danica and Miljković, Branislava and Varagić, V.M.",
year = "1991",
abstract = "Special interest in alternative approach to clinical pharmacokinetic research nowadays, especially in pediatric practice, is concerned on biological fluids obtainable by non- invasive methodology. Saliva and urine are the most interesting fluids in this approach. The possibility of using saliva and urine was investigated and evaluated in theophylline (Th) therapy, both in asthmatic children and adults. The investigation on drug presence in saliva (asthmatic children and adults) and in urine (asthmatic children) during Th therapy, confirmed good correlation between saliva and plasma, and between urine and plasma, and provided reliable basis for the conclusion that both saliva and urine can be used in pharmacokinetic research of The elimination in asthmatic children. Only saliva was investigated in adult patients and it was found that it can be used as alternative biological fluid in pharmacokinetic research, but with less reliability than in children.",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.",
pages = "513-518",
url = "https://hdl.handle.net/21.15107/rcub_farfar_90"
}
Pokrajac, M., Agbaba, D., Miljković, B.,& Varagić, V.M.. (1991). When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.. in European Journal of Drug Metabolism and Pharmacokinetics, 513-518.
https://hdl.handle.net/21.15107/rcub_farfar_90
Pokrajac M, Agbaba D, Miljković B, Varagić V. When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.. in European Journal of Drug Metabolism and Pharmacokinetics. 1991;:513-518.
https://hdl.handle.net/21.15107/rcub_farfar_90 .
Pokrajac, Milena, Agbaba, Danica, Miljković, Branislava, Varagić, V.M., "When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline." in European Journal of Drug Metabolism and Pharmacokinetics (1991):513-518,
https://hdl.handle.net/21.15107/rcub_farfar_90 .
