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Cost-effectiveness analysis in diagnosis of coronary artery disease: Choice of laboratory markers

Authorized Users Only
2007
Authors
Bogavac-Stanojević, Nataša
Petrova, Guenka
Jelić-Ivanović, Zorana
Memon, Lidija
Spasić, Slavica
Article (Published version)
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Abstract
Objectives: The aim of our study was to determine the cost-effectiveness of coronary artery disease (CAD) diagnostic parameters in a clinical laboratory setting. Design and methods: The effectiveness of apolipoproteins, lipoproteins and high sensitivity C-reactive protein (hs-CRP) supplementary to Framingham scoring data within a CAD risk assessment procedure was established in 221 CAD patients and 289 controls. The total costs of diagnostic procedures were calculated and incremental cost-effectiveness analysis was applied. Results: A diagnostic strategy employing Framingham calculation followed by apolipoprotein A-I (apoA-I) had the lowest cost per additional successfully diagnosed patient than the same strategy followed by hs-CRP in the low (2.63 vs. 24.47 euros) and intermediate-risk groups (2.96 vs. 122.85 euros). in the high-risk group the diagnostic strategy employing apoA-I saved 9.14 euros in comparison to the strategy employing hs-CRP. Conclusion: Cost-effectiveness analysis o...f different diagnostic markers results in improved identification of at-risk patients at a lower health cost for society.

Keywords:
cost-effectiveness / coronary artery disease / lipids / lipoproteins / Apolipoproteins / hs-CRP
Source:
Clinical Biochemistry, 2007, 40, 16-17, 1180-1187
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.clinbiochem.2007.07.004

ISSN: 0009-9120

PubMed: 17869234

WoS: 000250605200002

Scopus: 2-s2.0-35248865222
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/903
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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