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Role of alpha 2-adrenoceptors in the local peripheral antinociception by carbamazepine in a rat model of inflammatory mechanical hyperalgesia
dc.creator | Vučković, Sonja M. | |
dc.creator | Tomić, Maja | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Prostran, Milica | |
dc.creator | Bošković, Bogdan | |
dc.date.accessioned | 2019-09-02T11:09:03Z | |
dc.date.available | 2019-09-02T11:09:03Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0379-0355 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/904 | |
dc.description.abstract | The anticonvulsant carbamazepine was recently shown to possess local peripheral antinociceptive properties. In this study, we investigated whether alpha 2-adrenergic receptors are involved in the local peripheral antihyperalgesic effects of carbamazepine and determined the type of interaction between carbamazepine and clonidine, an alpha 2-adrenoceptor agonist. Intraplantar (i.pl.) coadministration of either carbamazepine (100-1000 nmol/paw) or clonidine (1.9-3.7 nmol/paw) with the proinflammatory compound concanavalin A (Con A; 0.8 mg/paw) caused a significant dose- and time-dependent reduction of the difference between the forces exerted by a rat's hind paws in a modified paw-pressure test. The coadministration of 260 and 520 nmol/paw (i.pl.) yohimbine, an alpha 2-adrenoceptor antagonist, with carbamazepine, significantly depressed the local antihyperalgesic effect in a dose- and time-dependent manner whereas yohimbine by itself did not have any effect. The administration of a mixture of carbamazepine and clonidine at fixed dose fractions (114, 112 and 314) of ED50 caused a significant and dose-dependent reduction of Con A-induced hyperalgesia. Isobolographic analysis revealed an additive interaction. These results suggest that alpha 2-adrenoceptors play a role in the local peripheral antihyperalgesic effects of carbamazepine and that local peripheral coadministration of carbamazepine with clonidine results in an additive antihyperalgesic effect. | en |
dc.publisher | Prous Science, Sa, Barcelona | |
dc.rights | restrictedAccess | |
dc.source | Methods and Findings in Experimental and Clinical Pharmacology | |
dc.subject | additive interaction | en |
dc.subject | carbamazepine | en |
dc.subject | clonidine | en |
dc.subject | inflammatory hyperalgesia | en |
dc.subject | isobolographic analysis | en |
dc.subject | local administration | en |
dc.subject | peripheral alpha 2-adrenoceptors | en |
dc.subject | yohimbine | en |
dc.title | Role of alpha 2-adrenoceptors in the local peripheral antinociception by carbamazepine in a rat model of inflammatory mechanical hyperalgesia | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Бошковић, Богдан; Простран, Милица; Степановић-Петровић, Радица; Вучковић, Соња М.; Томић, Маја; Угрешић, Ненад; | |
dc.citation.volume | 29 | |
dc.citation.issue | 10 | |
dc.citation.spage | 689 | |
dc.citation.epage | 696 | |
dc.citation.other | 29(10): 689-696 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000252779800005 | |
dc.identifier.doi | 10.1358/mf.2007.29.10.1147773 | |
dc.identifier.pmid | 18200332 | |
dc.identifier.scopus | 2-s2.0-39149128222 | |
dc.type.version | publishedVersion |
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