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dc.creatorJelić-Ivanović, Zorana
dc.creatorMemon, Lidija
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorBogavac-Stanojević, Nataša
dc.creatorSpasić, Slavica
dc.date.accessioned2019-09-02T11:09:05Z
dc.date.available2019-09-02T11:09:05Z
dc.date.issued2007
dc.identifier.issn0040-8727
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/907
dc.description.abstractEpidemiological studies have shown that a high serum uric acid concentration is a risk factor for coronary artery disease (CAD). However, the issue of whether it is an independent cardiovascular risk factor or simply a marker of co-existing conditions is a matter of controversy. In the present case-controlled study, we explored the association between serum uric acid and angiographically defined CAD in middle-aged subjects (356 CAD patients and 350 healthy individuals). Serum uric acid in CAD patients was significantly higher than that in healthy individuals (359 +/- 88.7 and 289 +/- 79.3 mu mol/l, respectively, p lt 0.01) and remained significantly higher after adjusting for confounding factors (F = 79.77, p lt 0.01). The association between uric acid and CAD was not limited to the hyperuricemic range of values, but was also found in the high-normal range (p lt 0.01). An unadjusted odds ratio (OR) of 5.0 was obtained in both genders (p lt 0.01). Female patients with > 50% stenosis (clinically significant CAD), regardless of the number of diseased vessels, had higher uric acid concentrations than those with lt 50% stenosis even after adjusting for confounders (F = 3.79, p = 0.01). In conclusion, we have demonstrated that high serum uric acid is independently associated with CAD and that uric acid determination could be useful as one of the markers of clinically significant CAD.en
dc.publisherTohoku Univ Medical Press, Sendai
dc.rightsopenAccess
dc.sourceToxicological and Environmental Chemistry
dc.subjectangiographyen
dc.subjectatherosclerosisen
dc.subjectcoronary heart diseaseen
dc.subjectrisk factorsen
dc.subjecturic aciden
dc.titleIndependent association of high serum uric acid concentration with angiographically defined coronary artery diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасић, Славица; Мемон, Лидија; Јелић-Ивановић, Зорана; Богавац-Станојевић, Наташа; Спасојевић-Калимановска, Весна;
dc.citation.volume211
dc.citation.issue4
dc.citation.spage369
dc.citation.epage377
dc.citation.other211(4): 369-377
dc.citation.rankM22
dc.identifier.wos000245644200008
dc.identifier.doi10.1620/tjem.211.369
dc.identifier.pmid17409677
dc.identifier.scopus2-s2.0-34247159137
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2256/905.pdf
dc.identifier.rcubconv_1842
dc.type.versionpublishedVersion


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