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Independent association of high serum uric acid concentration with angiographically defined coronary artery disease
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Memon, Lidija | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Bogavac-Stanojević, Nataša | |
dc.creator | Spasić, Slavica | |
dc.date.accessioned | 2019-09-02T11:09:05Z | |
dc.date.available | 2019-09-02T11:09:05Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0040-8727 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/907 | |
dc.description.abstract | Epidemiological studies have shown that a high serum uric acid concentration is a risk factor for coronary artery disease (CAD). However, the issue of whether it is an independent cardiovascular risk factor or simply a marker of co-existing conditions is a matter of controversy. In the present case-controlled study, we explored the association between serum uric acid and angiographically defined CAD in middle-aged subjects (356 CAD patients and 350 healthy individuals). Serum uric acid in CAD patients was significantly higher than that in healthy individuals (359 +/- 88.7 and 289 +/- 79.3 mu mol/l, respectively, p lt 0.01) and remained significantly higher after adjusting for confounding factors (F = 79.77, p lt 0.01). The association between uric acid and CAD was not limited to the hyperuricemic range of values, but was also found in the high-normal range (p lt 0.01). An unadjusted odds ratio (OR) of 5.0 was obtained in both genders (p lt 0.01). Female patients with > 50% stenosis (clinically significant CAD), regardless of the number of diseased vessels, had higher uric acid concentrations than those with lt 50% stenosis even after adjusting for confounders (F = 3.79, p = 0.01). In conclusion, we have demonstrated that high serum uric acid is independently associated with CAD and that uric acid determination could be useful as one of the markers of clinically significant CAD. | en |
dc.publisher | Tohoku Univ Medical Press, Sendai | |
dc.rights | openAccess | |
dc.source | Toxicological and Environmental Chemistry | |
dc.subject | angiography | en |
dc.subject | atherosclerosis | en |
dc.subject | coronary heart disease | en |
dc.subject | risk factors | en |
dc.subject | uric acid | en |
dc.title | Independent association of high serum uric acid concentration with angiographically defined coronary artery disease | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Спасић, Славица; Мемон, Лидија; Јелић-Ивановић, Зорана; Богавац-Станојевић, Наташа; Спасојевић-Калимановска, Весна; | |
dc.citation.volume | 211 | |
dc.citation.issue | 4 | |
dc.citation.spage | 369 | |
dc.citation.epage | 377 | |
dc.citation.other | 211(4): 369-377 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000245644200008 | |
dc.identifier.doi | 10.1620/tjem.211.369 | |
dc.identifier.pmid | 17409677 | |
dc.identifier.scopus | 2-s2.0-34247159137 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2256/905.pdf | |
dc.type.version | publishedVersion |