Show simple item record

dc.creatorĐukić, Mirjana
dc.creatorĆurčić-Jovanović, Marijana
dc.creatorNinković, Milica
dc.creatorVasijević, Ivana
dc.creatorJovanović, Marina
dc.date.accessioned2019-09-02T11:09:11Z
dc.date.available2019-09-02T11:09:11Z
dc.date.issued2007
dc.identifier.issn1232-1966
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/908
dc.description.abstractThe role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used N-G-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O-2(center dot-)), malondialdehyde (MDA) and nitrate (NO3-), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confirm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.en
dc.publisherInst Agricultural Medicine, Lublin
dc.rightsopenAccess
dc.sourceAnnals of Agricultural and Environmental Medicine
dc.subjectparaquaten
dc.subjectoxidative stressen
dc.subjectnitric oxideen
dc.subjectL-NAMEen
dc.subjectWistar ratsen
dc.subjectbrainen
dc.titleThe role of nitric oxide in paraquat-induced oxidative stress in rat striatumen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractВасијевић, Ивана; Нинковић, Милица; Чурчић-Јовановић, Маријана; Ђукић, Мирјана; Јовановић, Марина;
dc.citation.volume14
dc.citation.issue2
dc.citation.spage247
dc.citation.epage252
dc.citation.other14(2): 247-252
dc.citation.rankM23
dc.identifier.wos000251983800011
dc.identifier.pmid18247460
dc.identifier.scopus2-s2.0-39649120352
dc.identifier.rcubconv_1947
dc.type.versionpublishedVersion


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record