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dc.creatorJelikić-Stankov, Milena
dc.creatorUskoković-Marković, Snežana
dc.creatorHolclajtner-Antunović, Ivanka
dc.creatorTodorović, Marija R.
dc.creatorĐurđević, Predrag
dc.date.accessioned2019-09-02T11:09:14Z
dc.date.available2019-09-02T11:09:14Z
dc.date.issued2007
dc.identifier.issn0946-672X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/912
dc.description.abstractMolybdenum, vanadium and tungsten compounds are widely applied as analytical reagents for determination of numerous pharmacologically active substances and different biochemical parameters. Recent data from the available literature pointed to a very potent biomedical activity of compounds containing these trace elements. The present paper represents a survey on the structure and chemical properties of these compounds, as well as on their biological activity, mostly based on their interaction with cations of biomolecules, such as phospholipids and proteins. Besides, their potent inhibitory effects on cellular targets, bacterial and viral DNA and RNA polymerases will be discussed, as well. Numerous authors clearly demonstrated the antiviral (especially anti-HIV), anticoagulant and antineoplastic properties of the compounds containing the above trace elements. It has been also shown that these compounds act on some cellular enzymatic systems leading to the normalisation of blood pressure, blood glucose and serum lipid levels. Also, compounds of these trace elements represent potent antiobesity agents and express hepatoprotective and antioxidative stress activity.en
dc.publisherElsevier Gmbh, Urban & Fischer Verlag, Jena
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142047/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Trace Elements in Medicine and Biology
dc.subjectmolybdenumen
dc.subjectvanadiumen
dc.subjecttungstenen
dc.subjectbiomedical activityen
dc.titleCompounds of Mo, V and W in biochemistry and their biomedical activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractУскоковић-Марковић, Снежана; Холцлајтнер-Aнтуновић, Иванка; Тодоровић, Марија; Ђурђевић, Предраг; Јеликић-Станков, Милена;
dc.citation.volume21
dc.citation.issue1
dc.citation.spage8
dc.citation.epage16
dc.citation.other21(1): 8-16
dc.citation.rankM22
dc.identifier.wos000245350300002
dc.identifier.doi10.1016/j.jtemb.2006.11.004
dc.identifier.pmid17317520
dc.identifier.scopus2-s2.0-33847195018
dc.identifier.rcubconv_1838
dc.type.versionpublishedVersion


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