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Mikroorganizmi i čovek

dc.creatorMilenković, Marina
dc.date.accessioned2019-09-02T11:09:19Z
dc.date.available2019-09-02T11:09:19Z
dc.date.issued2007
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/914
dc.description.abstractMicroorganisms play a critical role in human survival. The microbial flora that colonizes the human body is numerous and diverse. The normal commensal population of microbes participates in the metabolism of food products, provides essential growth factors, protects against infections with highly virulent microorganisms, and stimulates the immune response. The microbial flora in and on the human body is in a continual state of flux determined by a variety of factors, such as age, diet, hormonal state, health, and personal hygiene. Changes in health can drastically disrupt the delicate balance that is maintained among the heterogeneous organisms coexisting within us. Organisms that colonize humans do not interfere with normal body functions. In contrast, disease occurs when the interaction between microbe and human leads to a pathologic process characterized by damage to the human host. This process can result from microbial factors (the proliferation of the microbe, toxins or cytotoxic enzymes) or the host's immune response to the organism. Antibiotic treatment can rapidly alter the microbial population causing the proliferation of antibiotic-resistant organisms such as Enterococcus, Pseudomonas, and fungi. Clostridium difficile can also grow rapidly in this situation, leading to diseases ranging from diarrhea to pseudomembranous colitis.en
dc.description.abstractMikroorganizmi imaju značajnu ulogu u preživljavanju humane vrste. Populacija mikroorganizama koja kolonizuje organizam čoveka je brojna i raznovrsna. Ona učestvuje u metaboličkim procesima, sintetiše vitamine, štiti organizam od infekcije virulentnim patogenima i konstantno stimuliše imunski sistem organizma. Sastav fiziološke mikroflore se menja tokom života i uslovljen je brojnim faktorima kao što su starosna dob, ishrana, hormonski status organizma, lična higijena i zdravstveno stanje organizma. U toku različitih patoloških stanja može doći do značajnog narušavanja fine ravnoteže koja postoji između mikroorganizama i humanog organizma. Fiziološka mikroflora u organizmu čoveka ne dovodi do oštećenja njegove funkcije. Nasuprot tome, bolest se razvija kada u toku interakcije mikroorganizam-čovek dođe do patološkog procesa i oštećenja funkcije organizma. Patološki proces može biti uzrokovan samim mikroorganizmom (proliferacijom i produkcijom različitih toksina i enzima) ili prekomernim imunskim odgovorom organizma. Primena antibiotika može dovesti do brze i značajne izmene populacije fiziološke mikroflore i prekomernog rasta rezistentnih sojeva bakterija (Enterococcus, Pseudomonas) i gljivica. Clostridium difficile je vrsta koja ubrzano proliferiše u tim slučajevima dovodeći do patoloških stanja koja se mogu različito manifestovati počev od dijareja do pseudomembranoznog enterokolitisa.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subjectnormal floraen
dc.subjectpathogensen
dc.subjectopportunistic infectionsen
dc.subjectfiziološka mikroflorasr
dc.subjectpatogeni mikroorganizmisr
dc.subjectoportunističke infekcijesr
dc.titleMicroorganisms and humansen
dc.titleMikroorganizmi i čoveksr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractМиленковић, Марина; Микроорганизми и човек; Микроорганизми и човек;
dc.citation.volume57
dc.citation.issue4-5
dc.citation.spage231
dc.citation.epage238
dc.citation.other57(4-5): 231-238
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2261/912.pdf
dc.identifier.rcubconv_358
dc.type.versionpublishedVersion


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