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dc.creatorPešić, V.
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorRadojević, Katarina
dc.creatorKosec, Duško
dc.creatorPilipović, Ivan
dc.creatorPerišić, M.
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:09:21Z
dc.date.available2019-09-02T11:09:21Z
dc.date.issued2007
dc.identifier.issn1567-5769
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/916
dc.description.abstractAge-related increase in the density of thymic noradrenergic fibres and noradrenaline (NA) concentration is proposed to be associated with thymic involution and altered thymopoiesis. To test this hypothesis thymocyte differentiation/maturation and thymic structure were studied in 18-month-old male Wistar rats subjected to 14-day-long propranolol (P) blockade of ss-adrenoceptors (ss-ARs). The treatment primarily resulted in changes in the T-cell receptor (TCR)-dependent stages of thymopoiesis, which led to an increase in both the relative and absolute numbers of the most mature single positive (SP) CD4(+)CD8(-) (including cells with the CD4(+)CD25(+) regulatory phenotype) and CD4(-)CD8(+) TCR alpha ss(high) thymocytes. Accordingly, in the thymi of these rats an increase in both numerical density and absolute number of medullary thymocytes encompassing mainly the most mature SP cells was found. These findings, together with an increase in the thymocyte surface expression of the regulatory molecule Thy-1 (CD90) (implicated in negative regulation of TCR alpha beta-dependent thymocyte selection thresholds) in the same rats, may suggest increased positive/reduced negative thymocyte selection. Collectively, the results indicate that a decline in thymic efficiency in generating both conventional and regulatory T cells, and consequently in immune function, in aged rats may be, at least partly, attenuated by long-term blockade of beta-ARs with P.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Immunopharmacology
dc.subjectbeta-adrenoceptor blockadeen
dc.subjectageingen
dc.subjectthymocyte differentiation/maturationen
dc.subjectCD90 expressionen
dc.titleLong-term beta-adrenergic receptor blockade increases levels of the most mature thymocyte subsets in aged ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПлећаш-Соларовић, Босиљка; Лепосавић, Гордана; Перишић, М.; Пешић, В.; Пилиповић, Иван; Косец, Душко; Радојевић, Катарина;
dc.citation.volume7
dc.citation.issue5
dc.citation.spage674
dc.citation.epage686
dc.citation.other7(5): 674-686
dc.citation.rankM22
dc.identifier.wos000245971800013
dc.identifier.doi10.1016/j.intimp.2007.01.017
dc.identifier.pmid17386415
dc.identifier.scopus2-s2.0-33947363946
dc.identifier.rcubconv_1845
dc.type.versionpublishedVersion


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