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The clinical pharmacological correlation between amitriptyline dosage and side effects

Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata

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Authors
Timotijević-Marković, Ivana
Pokrajac, Milena
Miljković, Branislava
Stojković, Mirjana
Veličković, Ružica
Article (Published version)
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Abstract
The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.
Source:
Psihijatrija danas, 1992, 24, 3-4, 231-249
Publisher:
  • Institut za mentalno zdravlje, Beograd

ISSN: 0350-2538

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_farfar_92
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/92
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Timotijević-Marković, Ivana
AU  - Pokrajac, Milena
AU  - Miljković, Branislava
AU  - Stojković, Mirjana
AU  - Veličković, Ružica
PY  - 1992
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/92
AB  - The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.
PB  - Institut za mentalno zdravlje, Beograd
T2  - Psihijatrija danas
T1  - The clinical pharmacological correlation between amitriptyline dosage and side effects
T1  - Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata
VL  - 24
IS  - 3-4
SP  - 231
EP  - 249
UR  - https://hdl.handle.net/21.15107/rcub_farfar_92
ER  - 
@article{
author = "Timotijević-Marković, Ivana and Pokrajac, Milena and Miljković, Branislava and Stojković, Mirjana and Veličković, Ružica",
year = "1992",
abstract = "The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.",
publisher = "Institut za mentalno zdravlje, Beograd",
journal = "Psihijatrija danas",
title = "The clinical pharmacological correlation between amitriptyline dosage and side effects, Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata",
volume = "24",
number = "3-4",
pages = "231-249",
url = "https://hdl.handle.net/21.15107/rcub_farfar_92"
}
Timotijević-Marković, I., Pokrajac, M., Miljković, B., Stojković, M.,& Veličković, R.. (1992). The clinical pharmacological correlation between amitriptyline dosage and side effects. in Psihijatrija danas
Institut za mentalno zdravlje, Beograd., 24(3-4), 231-249.
https://hdl.handle.net/21.15107/rcub_farfar_92
Timotijević-Marković I, Pokrajac M, Miljković B, Stojković M, Veličković R. The clinical pharmacological correlation between amitriptyline dosage and side effects. in Psihijatrija danas. 1992;24(3-4):231-249.
https://hdl.handle.net/21.15107/rcub_farfar_92 .
Timotijević-Marković, Ivana, Pokrajac, Milena, Miljković, Branislava, Stojković, Mirjana, Veličković, Ružica, "The clinical pharmacological correlation between amitriptyline dosage and side effects" in Psihijatrija danas, 24, no. 3-4 (1992):231-249,
https://hdl.handle.net/21.15107/rcub_farfar_92 .

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