The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.
TY - JOUR
AU - Timotijević-Marković, Ivana
AU - Pokrajac, Milena
AU - Miljković, Branislava
AU - Stojković, Mirjana
AU - Veličković, Ružica
PY - 1992
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/92
AB - The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.
PB - Institut za mentalno zdravlje, Beograd
T2 - Psihijatrija danas
T1 - The clinical pharmacological correlation between amitriptyline dosage and side effects
T1 - Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata
VL - 24
IS - 3-4
SP - 231
EP - 249
ER -
@article{
author = "Timotijević-Marković, Ivana and Pokrajac, Milena and Miljković, Branislava and Stojković, Mirjana and Veličković, Ružica",
year = "1992",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/92",
abstract = "The application of tryciclic antidepressants amitriptyline in the therapy of depression is followed by some side effects both those muscarinic and antihistaminic and alpha-adrenergic effects. The manifested degree of side effects directly correlates with the dosage and concentration in plasma, so that maximal effects are manifested when drug concentration in patient's plasma is maximal. When amitriptyline is used in the therapy an effective drug dosage enabling the maximal therapeutic effect and minimal side effects should be determined. By this the maximal outcome of the therapy is made possible.",
publisher = "Institut za mentalno zdravlje, Beograd",
journal = "Psihijatrija danas",
title = "The clinical pharmacological correlation between amitriptyline dosage and side effects, Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata",
volume = "24",
number = "3-4",
pages = "231-249"
}
Timotijević-Marković, I., Pokrajac, M., Miljković, B., Stojković, M.,& Veličković, R. (1992). Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata.
Psihijatrija danas
Institut za mentalno zdravlje, Beograd., 24(3-4), 231-249.
Timotijević-Marković I, Pokrajac M, Miljković B, Stojković M, Veličković R. Kliničko-farmakološka korelacija doza amitriptilina i neželjenih efekata. Psihijatrija danas. 1992;24(3-4):231-249
