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Chromatographic determination of dissociation constants of pramipexole and its impurities

Authorized Users Only
2007
Authors
Jančić, Biljana
Medenica, Mirjana
Ivanović, D.
Malenović, Anđelija
Article (Published version)
Metadata
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Abstract
The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.
Keywords:
column liquid chromatography / dissociation constants / impurities / pramipexole
Source:
Chromatographia, 2007, 65, 9-10, 633-635
Publisher:
  • Vieweg, Wiesbaden
Funding / projects:
  • Formulisanje i Karakterizacija separacionih sistema za modelovanje retencionog ponašanja lekovitih supstancija uz hemometrijsku evaluaciju (RS-142077)

DOI: 10.1365/s10337-007-0199-5

ISSN: 0009-5893

WoS: 000246878900021

Scopus: 2-s2.0-34247844409
[ Google Scholar ]
10
10
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/920
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Jančić, Biljana
AU  - Medenica, Mirjana
AU  - Ivanović, D.
AU  - Malenović, Anđelija
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/920
AB  - The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.
PB  - Vieweg, Wiesbaden
T2  - Chromatographia
T1  - Chromatographic determination of dissociation constants of pramipexole and its impurities
VL  - 65
IS  - 9-10
SP  - 633
EP  - 635
DO  - 10.1365/s10337-007-0199-5
ER  - 
@article{
author = "Jančić, Biljana and Medenica, Mirjana and Ivanović, D. and Malenović, Anđelija",
year = "2007",
abstract = "The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "Chromatographic determination of dissociation constants of pramipexole and its impurities",
volume = "65",
number = "9-10",
pages = "633-635",
doi = "10.1365/s10337-007-0199-5"
}
Jančić, B., Medenica, M., Ivanović, D.,& Malenović, A.. (2007). Chromatographic determination of dissociation constants of pramipexole and its impurities. in Chromatographia
Vieweg, Wiesbaden., 65(9-10), 633-635.
https://doi.org/10.1365/s10337-007-0199-5
Jančić B, Medenica M, Ivanović D, Malenović A. Chromatographic determination of dissociation constants of pramipexole and its impurities. in Chromatographia. 2007;65(9-10):633-635.
doi:10.1365/s10337-007-0199-5 .
Jančić, Biljana, Medenica, Mirjana, Ivanović, D., Malenović, Anđelija, "Chromatographic determination of dissociation constants of pramipexole and its impurities" in Chromatographia, 65, no. 9-10 (2007):633-635,
https://doi.org/10.1365/s10337-007-0199-5 . .

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