The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.
TY - JOUR
AU - Jančić, Biljana
AU - Medenica, Mirjana
AU - Ivanović, D.
AU - Malenović, Anđelija
PY - 2007
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/920
AB - The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.
PB - Vieweg, Wiesbaden
T2 - Chromatographia
T1 - Chromatographic determination of dissociation constants of pramipexole and its impurities
VL - 65
IS - 9-10
SP - 633
EP - 635
DO - 10.1365/s10337-007-0199-5
ER -
@article{
author = "Jančić, Biljana and Medenica, Mirjana and Ivanović, D. and Malenović, Anđelija",
year = "2007",
abstract = "The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "Chromatographic determination of dissociation constants of pramipexole and its impurities",
volume = "65",
number = "9-10",
pages = "633-635",
doi = "10.1365/s10337-007-0199-5"
}
Jančić, B., Medenica, M., Ivanović, D.,& Malenović, A.. (2007). Chromatographic determination of dissociation constants of pramipexole and its impurities. in Chromatographia
Vieweg, Wiesbaden., 65(9-10), 633-635.
https://doi.org/10.1365/s10337-007-0199-5
Jančić B, Medenica M, Ivanović D, Malenović A. Chromatographic determination of dissociation constants of pramipexole and its impurities. in Chromatographia. 2007;65(9-10):633-635.
doi:10.1365/s10337-007-0199-5 .
Jančić, Biljana, Medenica, Mirjana, Ivanović, D., Malenović, Anđelija, "Chromatographic determination of dissociation constants of pramipexole and its impurities" in Chromatographia, 65, no. 9-10 (2007):633-635,
https://doi.org/10.1365/s10337-007-0199-5 . .
