Chromatographic determination of dissociation constants of pramipexole and its impurities
Само за регистроване кориснике
2007
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.
Кључне речи:
column liquid chromatography / dissociation constants / impurities / pramipexoleИзвор:
Chromatographia, 2007, 65, 9-10, 633-635Издавач:
- Vieweg, Wiesbaden
Финансирање / пројекти:
- Формулисање и Карактеризација сепарационих система за моделовање ретенционог понашања лековитих супстанција уз хемометријску евалуацију (RS-MESTD-MPN2006-2010-142077)
DOI: 10.1365/s10337-007-0199-5
ISSN: 0009-5893
WoS: 000246878900021
Scopus: 2-s2.0-34247844409
Институција/група
PharmacyTY - JOUR AU - Jančić, Biljana AU - Medenica, Mirjana AU - Ivanović, D. AU - Malenović, Anđelija PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/920 AB - The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase. PB - Vieweg, Wiesbaden T2 - Chromatographia T1 - Chromatographic determination of dissociation constants of pramipexole and its impurities VL - 65 IS - 9-10 SP - 633 EP - 635 DO - 10.1365/s10337-007-0199-5 ER -
@article{ author = "Jančić, Biljana and Medenica, Mirjana and Ivanović, D. and Malenović, Anđelija", year = "2007", abstract = "The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase.", publisher = "Vieweg, Wiesbaden", journal = "Chromatographia", title = "Chromatographic determination of dissociation constants of pramipexole and its impurities", volume = "65", number = "9-10", pages = "633-635", doi = "10.1365/s10337-007-0199-5" }
Jančić, B., Medenica, M., Ivanović, D.,& Malenović, A.. (2007). Chromatographic determination of dissociation constants of pramipexole and its impurities. in Chromatographia Vieweg, Wiesbaden., 65(9-10), 633-635. https://doi.org/10.1365/s10337-007-0199-5
Jančić B, Medenica M, Ivanović D, Malenović A. Chromatographic determination of dissociation constants of pramipexole and its impurities. in Chromatographia. 2007;65(9-10):633-635. doi:10.1365/s10337-007-0199-5 .
Jančić, Biljana, Medenica, Mirjana, Ivanović, D., Malenović, Anđelija, "Chromatographic determination of dissociation constants of pramipexole and its impurities" in Chromatographia, 65, no. 9-10 (2007):633-635, https://doi.org/10.1365/s10337-007-0199-5 . .