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Chromatographic determination of dissociation constants of pramipexole and its impurities
dc.creator | Jančić, Biljana | |
dc.creator | Medenica, Mirjana | |
dc.creator | Ivanović, D. | |
dc.creator | Malenović, Anđelija | |
dc.date.accessioned | 2019-09-02T11:09:28Z | |
dc.date.available | 2019-09-02T11:09:28Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0009-5893 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/920 | |
dc.description.abstract | The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic method is advantageous as a small amount of substance is needed and the degree of substance purity is less important. Analysis was carried out using stationary phases stable in a wide pH range. Triethylamonium phosphoric buffer was selected as appropriate pH controlling solution because it can cover a wide pH range. Detection was done on two different wavelengths, 262 nm for pramipexole, BI-II 751 xx and 2-aminobenzothiazole and at 326 nm for BI-II 546 CL. The constants were calculated from the typical sigmoidal curves of analyte obtained as retention factor versus the pH of the mobile phase. | en |
dc.publisher | Vieweg, Wiesbaden | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142077/RS// | |
dc.rights | restrictedAccess | |
dc.source | Chromatographia | |
dc.subject | column liquid chromatography | en |
dc.subject | dissociation constants | en |
dc.subject | impurities | en |
dc.subject | pramipexole | en |
dc.title | Chromatographic determination of dissociation constants of pramipexole and its impurities | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јанчић, Биљана; Меденица, Мирјана; Ивановић, Д.; Маленовић, Aнђелија; | |
dc.citation.volume | 65 | |
dc.citation.issue | 9-10 | |
dc.citation.spage | 633 | |
dc.citation.epage | 635 | |
dc.citation.other | 65(9-10): 633-635 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000246878900021 | |
dc.identifier.doi | 10.1365/s10337-007-0199-5 | |
dc.identifier.scopus | 2-s2.0-34247844409 | |
dc.type.version | publishedVersion |