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dc.creatorStepanović-Petrović, Radica
dc.creatorTomić, Maja
dc.creatorVučković, Sonja M.
dc.creatorUgrešić, Nenad
dc.creatorProstran, Milica
dc.creatorBošković, B
dc.date.accessioned2019-09-02T11:09:35Z
dc.date.available2019-09-02T11:09:35Z
dc.date.issued2007
dc.identifier.issn0379-0355
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/924
dc.description.abstractThe mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, on the antihyperalgesic effects of carbamazepine and oxcarbazepine were examined in the model of inflammatory hyperalgesia induced by the intraplantar (i.pl.) administration of concanavaline A (Con A, 0.8 mg/paw) into the rat hind paw. Naloxone (3 mg/kg; i.p.) did not alter the antihyperalgesic effects of either carbamazepine or axcarbazepine. These results indicate that the opioid system of pain modulation does not play a significant role in the antihyperalgesic effects of carbamazepine and oxcarbazepine.en
dc.publisherProus Science, Sau-Thomson Reuters, Barcelona
dc.rightsrestrictedAccess
dc.sourceMethods and Findings in Experimental and Clinical Pharmacology
dc.subjectcarbamazepineen
dc.subjectinflammatory hyperalgesiaen
dc.subjectnaloxoneen
dc.subjectopioid receptorsen
dc.subjectoxcarbazepineen
dc.titleOpioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПростран, Милица; Вучковић, Соња М.; Бошковић, Б.; Степановић-Петровић, Радица; Томић, Маја; Угрешић, Ненад;
dc.citation.volume29
dc.citation.issue3
dc.citation.spage191
dc.citation.epage194
dc.citation.other29(3): 191-194
dc.citation.rankM23
dc.identifier.wos000246979400003
dc.identifier.doi10.1358/mf.2007.29.3.1075352
dc.identifier.pmid17520100
dc.identifier.scopus2-s2.0-34250353535
dc.identifier.rcubconv_1857
dc.type.versionpublishedVersion


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