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dc.creatorMilenković, Marina
dc.creatorArsenović-Ranin, Nevena
dc.creatorVučićević, Dragana
dc.creatorBufan, Biljana
dc.creatorStojić-Vukanić, Zorica
dc.date.accessioned2019-09-02T11:09:41Z
dc.date.available2019-09-02T11:09:41Z
dc.date.issued2007
dc.identifier.issn0031-7144
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/928
dc.description.abstractExperimental autoimmune myocarditis (EAM) represents a model for human autoimmune myocarditis, a condition for which no optimal treatment is currently available. It has been reported that tumor necroc sis factor-alpha (TNF-alpha) plays a crucial role in pathogenesis of EAM. The immunomodulating antibiotic fusidic acid and its sodium salt (sodium fusidate-fusidin) were previously shown to reduce TNF-alpha production and its end-organ cytotoxicity, thus proving beneficial in several animal models of organ-specific autoimmune diseases. To investigate the effects of fusidin on EAM the drug was given at dose 80 mg/kg i.m. to EAM rats. Fusidin was administered as an early, from day 0 to 10, or late treatment, from day 10 to 21, after induction of disease. Both early and late treatment with fusidin markedly ameliorated the clinical and histological signs of the disease. Fusidin-treated rats had significantly decreased blood levels of TNF-alpha compared with vehicle-treated animals. Similarly, TNF-alpha production by in vitro sensitized lymph node cells in both fusidin treated groups was significantly lower than that in EAM rats. The present findings suggest that fusidin ameliorated EAM, at least partly, through an inhibitory action on the secretion of TNF-alpha.en
dc.publisherGovi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn
dc.rightsrestrictedAccess
dc.sourcePharmazie
dc.titleFusidin ameliorates experimental autoimmune myocarditis in rats by inhibiting TNF-alpha productionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрсеновић-Ранин, Невена; Вучићевић, Драгана; Стојић-Вуканић, Зорица; Миленков, М.; Буфан, Биљана;
dc.citation.volume62
dc.citation.issue6
dc.citation.spage445
dc.citation.epage448
dc.citation.other62(6): 445-448
dc.citation.rankM23
dc.identifier.wos000247364600010
dc.identifier.doi10.1691/ph.2007.6.6739
dc.identifier.pmid17663192
dc.identifier.scopus2-s2.0-34250889350
dc.identifier.rcubconv_1861
dc.type.versionpublishedVersion


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