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An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation

Authorized Users Only
2007
Authors
Savić, Snežana
Savić, M.
Tamburić, Slobodanka
Vuleta, G.
Vesić, Sonja
Mueller-Goymann, Christel
Article (Published version)
Metadata
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Abstract
There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles ba...sed on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.

Keywords:
alkylpolyglucoside / oil polarity / lamellar gel phase/liquid crystals / rheological behaviour / in vitro/in vivo permeation / hydrocortisone
Source:
European Journal of Pharmaceutical Sciences, 2007, 30, 5, 441-450
Publisher:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/j.ejps.2007.01.006

ISSN: 0928-0987

PubMed: 17331708

WoS: 000245816000010

Scopus: 2-s2.0-33947325828
[ Google Scholar ]
42
34
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/939
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Savić, Snežana
AU  - Savić, M.
AU  - Tamburić, Slobodanka
AU  - Vuleta, G.
AU  - Vesić, Sonja
AU  - Mueller-Goymann, Christel
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/939
AB  - There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation
VL  - 30
IS  - 5
SP  - 441
EP  - 450
DO  - 10.1016/j.ejps.2007.01.006
ER  - 
@article{
author = "Savić, Snežana and Savić, M. and Tamburić, Slobodanka and Vuleta, G. and Vesić, Sonja and Mueller-Goymann, Christel",
year = "2007",
abstract = "There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation",
volume = "30",
number = "5",
pages = "441-450",
doi = "10.1016/j.ejps.2007.01.006"
}
Savić, S., Savić, M., Tamburić, S., Vuleta, G., Vesić, S.,& Mueller-Goymann, C.. (2007). An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 30(5), 441-450.
https://doi.org/10.1016/j.ejps.2007.01.006
Savić S, Savić M, Tamburić S, Vuleta G, Vesić S, Mueller-Goymann C. An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. in European Journal of Pharmaceutical Sciences. 2007;30(5):441-450.
doi:10.1016/j.ejps.2007.01.006 .
Savić, Snežana, Savić, M., Tamburić, Slobodanka, Vuleta, G., Vesić, Sonja, Mueller-Goymann, Christel, "An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation" in European Journal of Pharmaceutical Sciences, 30, no. 5 (2007):441-450,
https://doi.org/10.1016/j.ejps.2007.01.006 . .

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