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dc.creatorSavić, Snežana
dc.creatorSavić, M.
dc.creatorTamburić, Slobodanka
dc.creatorVuleta, G.
dc.creatorVesić, Sonja
dc.creatorMueller-Goymann, Christel
dc.date.accessioned2019-09-02T11:09:58Z
dc.date.available2019-09-02T11:09:58Z
dc.date.issued2007
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/939
dc.description.abstractThere is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectalkylpolyglucosideen
dc.subjectoil polarityen
dc.subjectlamellar gel phase/liquid crystalsen
dc.subjectrheological behaviouren
dc.subjectin vitro/in vivo permeationen
dc.subjecthydrocortisoneen
dc.titleAn alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Снежана; Муеллер-Гоyманн, Цхристел; Вулета, Г.; Тамбурић, Слободанка; Савић, М.; Весић, Соња;
dc.citation.volume30
dc.citation.issue5
dc.citation.spage441
dc.citation.epage450
dc.citation.other30(5): 441-450
dc.citation.rankM21
dc.identifier.wos000245816000010
dc.identifier.doi10.1016/j.ejps.2007.01.006
dc.identifier.pmid17331708
dc.identifier.scopus2-s2.0-33947325828
dc.identifier.rcubconv_1844
dc.type.versionpublishedVersion


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