Dissolution assay of theophylline, diprophylline and proxyphylline from a sustained release dosage form by high performance thin layer chromatography
Abstract
The content and dissolution rate of theophylline, diprophylline and proxyphylline from a sustained release formulation were determined by UV in situ densitometry. After separation the chromatographic zones corresponding to the spots of theophylline, diprophylline and proxyphylline on the high performance thin layer chromatographic plates were scanned in reflectance/absorbance mode at 275 nm. Quantification was performed with a second degree polynomial function over the range 40–200 ng for theophylline and 60–300 ng for diprophylline and proxyphylline. Percentages of dissolved theophylline, diprophylline and proxyphylline were monitored over 1, 3 and 6 h. The method was found to be simple, accurate, reliable, time‐saving (up to 18 samples can be determined simultaneously) and low‐cost.
Source:
Biomedical Chromatography, 1992, 6, 3, 141-142Collections
Institution/Community
PharmacyTY - JOUR AU - Agbaba, Danica AU - Živanov-Stakić, Dobrila AU - Vukićević, N PY - 1992 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/93 AB - The content and dissolution rate of theophylline, diprophylline and proxyphylline from a sustained release formulation were determined by UV in situ densitometry. After separation the chromatographic zones corresponding to the spots of theophylline, diprophylline and proxyphylline on the high performance thin layer chromatographic plates were scanned in reflectance/absorbance mode at 275 nm. Quantification was performed with a second degree polynomial function over the range 40–200 ng for theophylline and 60–300 ng for diprophylline and proxyphylline. Percentages of dissolved theophylline, diprophylline and proxyphylline were monitored over 1, 3 and 6 h. The method was found to be simple, accurate, reliable, time‐saving (up to 18 samples can be determined simultaneously) and low‐cost. T2 - Biomedical Chromatography T1 - Dissolution assay of theophylline, diprophylline and proxyphylline from a sustained release dosage form by high performance thin layer chromatography VL - 6 IS - 3 SP - 141 EP - 142 DO - 10.1002/bmc.1130060309 ER -
@article{ author = "Agbaba, Danica and Živanov-Stakić, Dobrila and Vukićević, N", year = "1992", abstract = "The content and dissolution rate of theophylline, diprophylline and proxyphylline from a sustained release formulation were determined by UV in situ densitometry. After separation the chromatographic zones corresponding to the spots of theophylline, diprophylline and proxyphylline on the high performance thin layer chromatographic plates were scanned in reflectance/absorbance mode at 275 nm. Quantification was performed with a second degree polynomial function over the range 40–200 ng for theophylline and 60–300 ng for diprophylline and proxyphylline. Percentages of dissolved theophylline, diprophylline and proxyphylline were monitored over 1, 3 and 6 h. The method was found to be simple, accurate, reliable, time‐saving (up to 18 samples can be determined simultaneously) and low‐cost.", journal = "Biomedical Chromatography", title = "Dissolution assay of theophylline, diprophylline and proxyphylline from a sustained release dosage form by high performance thin layer chromatography", volume = "6", number = "3", pages = "141-142", doi = "10.1002/bmc.1130060309" }
Agbaba, D., Živanov-Stakić, D.,& Vukićević, N.. (1992). Dissolution assay of theophylline, diprophylline and proxyphylline from a sustained release dosage form by high performance thin layer chromatography. in Biomedical Chromatography, 6(3), 141-142. https://doi.org/10.1002/bmc.1130060309
Agbaba D, Živanov-Stakić D, Vukićević N. Dissolution assay of theophylline, diprophylline and proxyphylline from a sustained release dosage form by high performance thin layer chromatography. in Biomedical Chromatography. 1992;6(3):141-142. doi:10.1002/bmc.1130060309 .
Agbaba, Danica, Živanov-Stakić, Dobrila, Vukićević, N, "Dissolution assay of theophylline, diprophylline and proxyphylline from a sustained release dosage form by high performance thin layer chromatography" in Biomedical Chromatography, 6, no. 3 (1992):141-142, https://doi.org/10.1002/bmc.1130060309 . .