Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique
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2007
Authors
Pejić, Nataša
Blagojević, Slavica

Anić, Slobodan
Vukojević, Vladana

Mijatović, Miroslav D.
Ćirić, Jasna S.
Marković, Zoran S.

Marković, Svetlana D.

Kolar-Anić, Ljiljana

Article (Published version)

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A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was su...ccessfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.
Keywords:
morphine / Bray-Liebhafsky reaction / quantitative analysis / analyte pulse perturbation / kinetic methodSource:
Analytica Chimica Acta, 2007, 582, 2, 367-374Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.aca.2006.09.026
ISSN: 0003-2670
PubMed: 17386515
WoS: 000243665400024
Scopus: 2-s2.0-33845672241
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PharmacyTY - JOUR AU - Pejić, Nataša AU - Blagojević, Slavica AU - Anić, Slobodan AU - Vukojević, Vladana AU - Mijatović, Miroslav D. AU - Ćirić, Jasna S. AU - Marković, Zoran S. AU - Marković, Svetlana D. AU - Kolar-Anić, Ljiljana PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/942 AB - A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail. PB - Elsevier Science BV, Amsterdam T2 - Analytica Chimica Acta T1 - Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique VL - 582 IS - 2 SP - 367 EP - 374 DO - 10.1016/j.aca.2006.09.026 ER -
@article{ author = "Pejić, Nataša and Blagojević, Slavica and Anić, Slobodan and Vukojević, Vladana and Mijatović, Miroslav D. and Ćirić, Jasna S. and Marković, Zoran S. and Marković, Svetlana D. and Kolar-Anić, Ljiljana", year = "2007", abstract = "A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.", publisher = "Elsevier Science BV, Amsterdam", journal = "Analytica Chimica Acta", title = "Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique", volume = "582", number = "2", pages = "367-374", doi = "10.1016/j.aca.2006.09.026" }
Pejić, N., Blagojević, S., Anić, S., Vukojević, V., Mijatović, M. D., Ćirić, J. S., Marković, Z. S., Marković, S. D.,& Kolar-Anić, L.. (2007). Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique. in Analytica Chimica Acta Elsevier Science BV, Amsterdam., 582(2), 367-374. https://doi.org/10.1016/j.aca.2006.09.026
Pejić N, Blagojević S, Anić S, Vukojević V, Mijatović MD, Ćirić JS, Marković ZS, Marković SD, Kolar-Anić L. Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique. in Analytica Chimica Acta. 2007;582(2):367-374. doi:10.1016/j.aca.2006.09.026 .
Pejić, Nataša, Blagojević, Slavica, Anić, Slobodan, Vukojević, Vladana, Mijatović, Miroslav D., Ćirić, Jasna S., Marković, Zoran S., Marković, Svetlana D., Kolar-Anić, Ljiljana, "Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique" in Analytica Chimica Acta, 582, no. 2 (2007):367-374, https://doi.org/10.1016/j.aca.2006.09.026 . .