Приказ основних података о документу

dc.creatorPejić, Nataša
dc.creatorBlagojević, Slavica
dc.creatorAnić, Slobodan
dc.creatorVukojević, Vladana
dc.creatorMijatović, Miroslav D.
dc.creatorĆirić, Jasna S.
dc.creatorMarković, Zoran S.
dc.creatorMarković, Svetlana D.
dc.creatorKolar-Anić, Ljiljana
dc.date.accessioned2019-09-02T11:10:02Z
dc.date.available2019-09-02T11:10:02Z
dc.date.issued2007
dc.identifier.issn0003-2670
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/942
dc.description.abstractA novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142025/RS//
dc.rightsrestrictedAccess
dc.sourceAnalytica Chimica Acta
dc.subjectmorphineen
dc.subjectBray-Liebhafsky reactionen
dc.subjectquantitative analysisen
dc.subjectanalyte pulse perturbationen
dc.subjectkinetic methoden
dc.titleKinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation techniqueen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЋирић, Јасна С.; Марковић, Зоран С.; Мијатовић, Мирослав Д.; Марковић, Светлана Д.; Пејић, Наташа; Колар-Aнић, Љиљана; Aнић, Слободан; Вукојевић, Владана; Благојевић, Славица;
dc.citation.volume582
dc.citation.issue2
dc.citation.spage367
dc.citation.epage374
dc.citation.other582(2): 367-374
dc.citation.rankM21
dc.identifier.wos000243665400024
dc.identifier.doi10.1016/j.aca.2006.09.026
dc.identifier.pmid17386515
dc.identifier.scopus2-s2.0-33845672241
dc.type.versionpublishedVersion


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Приказ основних података о документу