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dc.creatorKotur-Stevuljević, Jelena
dc.creatorMemon, Lidija
dc.creatorStefanović, Aleksandra
dc.creatorSpasić, Slavica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorBogavac-Stanojević, Nataša
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorJelić-Ivanović, Zorana
dc.creatorZunić, Gordana
dc.date.accessioned2019-09-02T11:10:10Z
dc.date.available2019-09-02T11:10:10Z
dc.date.issued2007
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/947
dc.description.abstractObjectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectoxidative stressen
dc.subjectcoronary artery diseaseen
dc.subjectinflammationen
dc.titleCorrelation of oxidative stress parameters and inflammatory markers in coronary artery disease patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМемон, Лидија; Зунић, Гордана; Стефановић, Aлександра; Калимановска-Оштрић, Димитра; Котур-Стевуљевић, Јелена; Спасић, Славица; Спасојевић-Калимановска, Весна; Јелић-Ивановић, Зорана; Богавац-Станојевић, Наташа;
dc.citation.volume40
dc.citation.issue3-4
dc.citation.spage181
dc.citation.epage187
dc.citation.other40(3-4): 181-187
dc.citation.rankM22
dc.identifier.wos000244193000007
dc.identifier.doi10.1016/j.clinbiochem.2006.09.007
dc.identifier.pmid17070511
dc.identifier.scopus2-s2.0-33846287199
dc.identifier.rcubconv_1823
dc.type.versionpublishedVersion


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