The influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersions
Samo za registrovane korisnike
1992
Članak u časopisu (Objavljena verzija)
Metapodaci
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Abstract— The effect of cyclodextrin (β‐CD) on the solubility and dissolution rate of various paracetamol dispersion powders (1:1 w/w), and tablets was studied. Lower solubility was exhibited by a spray dried solid dispersion made from paracetamol‐Ethocel‐Macrogol 6000 (95:2:3). The improvement in solubility was influenced by complexation with β‐CD and the crystalline nature of the powder products made by different procedures. The difference in crystallinity was confirmed by X‐ray powder diffraction patterns. The dissolution rate of paracetamol from tablets made from the solid dispersions was satisfactory compared with paracetamol alone. The differences between the dissolution rate from the examined paracetamol tablets resulted from the different solubility of each powder and from the structural changes of particles which influenced the consolidation of the tablet mass. 1992 Royal Pharmaceutical Society of Great Britain
Izvor:
Journal of Pharmacy and Pharmacology, 1992, 44, 1, 52-55
DOI: 10.1111/j.2042-7158.1992.tb14363.x
ISSN: 0022-3573
Scopus: 2-s2.0-0026542550
Institucija/grupa
PharmacyTY - JOUR AU - Tasić, Ljiljana AU - Jovanović, M.D AU - Đurić, Zorica PY - 1992 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/94 AB - Abstract— The effect of cyclodextrin (β‐CD) on the solubility and dissolution rate of various paracetamol dispersion powders (1:1 w/w), and tablets was studied. Lower solubility was exhibited by a spray dried solid dispersion made from paracetamol‐Ethocel‐Macrogol 6000 (95:2:3). The improvement in solubility was influenced by complexation with β‐CD and the crystalline nature of the powder products made by different procedures. The difference in crystallinity was confirmed by X‐ray powder diffraction patterns. The dissolution rate of paracetamol from tablets made from the solid dispersions was satisfactory compared with paracetamol alone. The differences between the dissolution rate from the examined paracetamol tablets resulted from the different solubility of each powder and from the structural changes of particles which influenced the consolidation of the tablet mass. 1992 Royal Pharmaceutical Society of Great Britain T2 - Journal of Pharmacy and Pharmacology T1 - The influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersions VL - 44 IS - 1 SP - 52 EP - 55 DO - 10.1111/j.2042-7158.1992.tb14363.x ER -
@article{ author = "Tasić, Ljiljana and Jovanović, M.D and Đurić, Zorica", year = "1992", abstract = "Abstract— The effect of cyclodextrin (β‐CD) on the solubility and dissolution rate of various paracetamol dispersion powders (1:1 w/w), and tablets was studied. Lower solubility was exhibited by a spray dried solid dispersion made from paracetamol‐Ethocel‐Macrogol 6000 (95:2:3). The improvement in solubility was influenced by complexation with β‐CD and the crystalline nature of the powder products made by different procedures. The difference in crystallinity was confirmed by X‐ray powder diffraction patterns. The dissolution rate of paracetamol from tablets made from the solid dispersions was satisfactory compared with paracetamol alone. The differences between the dissolution rate from the examined paracetamol tablets resulted from the different solubility of each powder and from the structural changes of particles which influenced the consolidation of the tablet mass. 1992 Royal Pharmaceutical Society of Great Britain", journal = "Journal of Pharmacy and Pharmacology", title = "The influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersions", volume = "44", number = "1", pages = "52-55", doi = "10.1111/j.2042-7158.1992.tb14363.x" }
Tasić, L., Jovanović, M.D,& Đurić, Z.. (1992). The influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersions. in Journal of Pharmacy and Pharmacology, 44(1), 52-55. https://doi.org/10.1111/j.2042-7158.1992.tb14363.x
Tasić L, Jovanović M, Đurić Z. The influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersions. in Journal of Pharmacy and Pharmacology. 1992;44(1):52-55. doi:10.1111/j.2042-7158.1992.tb14363.x .
Tasić, Ljiljana, Jovanović, M.D, Đurić, Zorica, "The influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersions" in Journal of Pharmacy and Pharmacology, 44, no. 1 (1992):52-55, https://doi.org/10.1111/j.2042-7158.1992.tb14363.x . .