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dc.creatorTasić, Ljiljana
dc.creatorJovanović, M.D
dc.creatorĐurić, Zorica
dc.date.accessioned2019-09-02T10:48:19Z
dc.date.available2019-09-02T10:48:19Z
dc.date.issued1992
dc.identifier.issn0022-3573
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/94
dc.description.abstractAbstract— The effect of cyclodextrin (β‐CD) on the solubility and dissolution rate of various paracetamol dispersion powders (1:1 w/w), and tablets was studied. Lower solubility was exhibited by a spray dried solid dispersion made from paracetamol‐Ethocel‐Macrogol 6000 (95:2:3). The improvement in solubility was influenced by complexation with β‐CD and the crystalline nature of the powder products made by different procedures. The difference in crystallinity was confirmed by X‐ray powder diffraction patterns. The dissolution rate of paracetamol from tablets made from the solid dispersions was satisfactory compared with paracetamol alone. The differences between the dissolution rate from the examined paracetamol tablets resulted from the different solubility of each powder and from the structural changes of particles which influenced the consolidation of the tablet mass. 1992 Royal Pharmaceutical Society of Great Britainen
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmacy and Pharmacology
dc.titleThe influence of β‐cyclodextrin on the solubility and dissolution rate of paracetamol solid dispersionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂурић, Зорица; Тасић, Љиљана; Јовановић, М.Д;
dc.citation.volume44
dc.citation.issue1
dc.citation.spage52
dc.citation.epage55
dc.citation.other44(1): 52-55
dc.citation.rankM22
dc.identifier.doi10.1111/j.2042-7158.1992.tb14363.x
dc.identifier.scopus2-s2.0-0026542550
dc.identifier.rcubconv_5509
dc.type.versionpublishedVersion


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