Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.
TY - JOUR
AU - Vučinić-Milanković, Nada
AU - Savić, Snežana
AU - Vuleta, Gordana
AU - Vučinić, Slavica
PY - 2007
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/950
AB - Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.
PB - Taylor & Francis Ltd, Abingdon
T2 - Drug Development and Industrial Pharmacy
T1 - The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine
VL - 33
IS - 3
SP - 221
EP - 234
DO - 10.1080/03639040601150179
ER -
@article{
author = "Vučinić-Milanković, Nada and Savić, Snežana and Vuleta, Gordana and Vučinić, Slavica",
year = "2007",
abstract = "Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine",
volume = "33",
number = "3",
pages = "221-234",
doi = "10.1080/03639040601150179"
}
Vučinić-Milanković, N., Savić, S., Vuleta, G.,& Vučinić, S.. (2007). The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 33(3), 221-234.
https://doi.org/10.1080/03639040601150179
Vučinić-Milanković N, Savić S, Vuleta G, Vučinić S. The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. in Drug Development and Industrial Pharmacy. 2007;33(3):221-234.
doi:10.1080/03639040601150179 .
Vučinić-Milanković, Nada, Savić, Snežana, Vuleta, Gordana, Vučinić, Slavica, "The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine" in Drug Development and Industrial Pharmacy, 33, no. 3 (2007):221-234,
https://doi.org/10.1080/03639040601150179 . .
