The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine
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2007
Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.
Ključne reči:
liquid-crystalline gel network / cetearyl alcohol & cetearyl glycoside / sorbitan stearate & sucrose cocoate / diclophenac diethylamine release / rheology / droplet size analysisIzvor:
Drug Development and Industrial Pharmacy, 2007, 33, 3, 221-234Izdavač:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/03639040601150179
ISSN: 0363-9045
PubMed: 17454055
WoS: 000246014400002
Scopus: 2-s2.0-34247475216
Institucija/grupa
PharmacyTY - JOUR AU - Vučinić-Milanković, Nada AU - Savić, Snežana AU - Vuleta, Gordana AU - Vučinić, Slavica PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/950 AB - Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle. PB - Taylor & Francis Ltd, Abingdon T2 - Drug Development and Industrial Pharmacy T1 - The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine VL - 33 IS - 3 SP - 221 EP - 234 DO - 10.1080/03639040601150179 ER -
@article{ author = "Vučinić-Milanković, Nada and Savić, Snežana and Vuleta, Gordana and Vučinić, Slavica", year = "2007", abstract = "Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Drug Development and Industrial Pharmacy", title = "The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine", volume = "33", number = "3", pages = "221-234", doi = "10.1080/03639040601150179" }
Vučinić-Milanković, N., Savić, S., Vuleta, G.,& Vučinić, S.. (2007). The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. in Drug Development and Industrial Pharmacy Taylor & Francis Ltd, Abingdon., 33(3), 221-234. https://doi.org/10.1080/03639040601150179
Vučinić-Milanković N, Savić S, Vuleta G, Vučinić S. The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. in Drug Development and Industrial Pharmacy. 2007;33(3):221-234. doi:10.1080/03639040601150179 .
Vučinić-Milanković, Nada, Savić, Snežana, Vuleta, Gordana, Vučinić, Slavica, "The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine" in Drug Development and Industrial Pharmacy, 33, no. 3 (2007):221-234, https://doi.org/10.1080/03639040601150179 . .