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dc.creatorVučinić-Milanković, Nada
dc.creatorSavić, Snežana
dc.creatorVuleta, Gordana
dc.creatorVučinić, Slavica
dc.date.accessioned2019-09-02T11:10:16Z
dc.date.available2019-09-02T11:10:16Z
dc.date.issued2007
dc.identifier.issn0363-9045
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/950
dc.description.abstractTwo sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceDrug Development and Industrial Pharmacy
dc.subjectliquid-crystalline gel networken
dc.subjectcetearyl alcohol & cetearyl glycosideen
dc.subjectsorbitan stearate & sucrose cocoateen
dc.subjectdiclophenac diethylamine releaseen
dc.subjectrheologyen
dc.subjectdroplet size analysisen
dc.titleThe physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВучинић-Миланковић, Нада; Вучинић, Славица; Савић, Снежана; Вулета, Гордана;
dc.citation.volume33
dc.citation.issue3
dc.citation.spage221
dc.citation.epage234
dc.citation.other33(3): 221-234
dc.citation.rankM23
dc.identifier.wos000246014400002
dc.identifier.doi10.1080/03639040601150179
dc.identifier.pmid17454055
dc.identifier.scopus2-s2.0-34247475216
dc.type.versionpublishedVersion


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