Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands
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The retention constant (110) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R-m(0) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R-m(0) versus apparent partition coefficient octanol-buffer pH 7.4 (log P-1) or apparent partition coefficient in four liposome systems (log K-M(1)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs.
Source:Journal of Chromatographic Science, 2007, 45, 3, 140-145
- Oxford Univ Press Inc, Cary