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LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population

Authorized Users Only
2007
Authors
Vekić, Jelena
Topić, Aleksandra
Zeljković, Aleksandra
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Article (Published version)
Metadata
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Abstract
Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P lt 0.001, and P lt 0.05, respectively), higher frequency of LDL B phenotype (P lt 0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P lt 0.05). The observed gender-related differences disappeared after the age of 60. We found a ...significant association of the small LDL particles with high FRS values (P lt 0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.

Keywords:
LDL particle size / HDL particle size / gradient gel electrophoresis / Framingham risk score
Source:
Clinical Biochemistry, 2007, 40, 5-6, 310-316
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.clinbiochem.2006.11.013

ISSN: 0009-9120

PubMed: 17291473

WoS: 000244997400005

Scopus: 2-s2.0-33847270332
[ Google Scholar ]
60
51
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/955
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vekić, Jelena
AU  - Topić, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/955
AB  - Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P  lt  0.001, and P  lt  0.05, respectively), higher frequency of LDL B phenotype (P  lt  0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P  lt  0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P  lt  0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population
VL  - 40
IS  - 5-6
SP  - 310
EP  - 316
DO  - 10.1016/j.clinbiochem.2006.11.013
ER  - 
@article{
author = "Vekić, Jelena and Topić, Aleksandra and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna",
year = "2007",
abstract = "Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P  lt  0.001, and P  lt  0.05, respectively), higher frequency of LDL B phenotype (P  lt  0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P  lt  0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P  lt  0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population",
volume = "40",
number = "5-6",
pages = "310-316",
doi = "10.1016/j.clinbiochem.2006.11.013"
}
Vekić, J., Topić, A., Zeljković, A., Jelić-Ivanović, Z.,& Spasojević-Kalimanovska, V.. (2007). LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(5-6), 310-316.
https://doi.org/10.1016/j.clinbiochem.2006.11.013
Vekić J, Topić A, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V. LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population. in Clinical Biochemistry. 2007;40(5-6):310-316.
doi:10.1016/j.clinbiochem.2006.11.013 .
Vekić, Jelena, Topić, Aleksandra, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, "LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population" in Clinical Biochemistry, 40, no. 5-6 (2007):310-316,
https://doi.org/10.1016/j.clinbiochem.2006.11.013 . .

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