LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population
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2007
Authors
Vekić, Jelena
Topić, Aleksandra

Zeljković, Aleksandra

Jelić-Ivanović, Zorana

Spasojević-Kalimanovska, Vesna

Article (Published version)

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Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P lt 0.001, and P lt 0.05, respectively), higher frequency of LDL B phenotype (P lt 0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P lt 0.05). The observed gender-related differences disappeared after the age of 60. We found a ...significant association of the small LDL particles with high FRS values (P lt 0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.
Keywords:
LDL particle size / HDL particle size / gradient gel electrophoresis / Framingham risk scoreSource:
Clinical Biochemistry, 2007, 40, 5-6, 310-316Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
DOI: 10.1016/j.clinbiochem.2006.11.013
ISSN: 0009-9120
PubMed: 17291473
WoS: 000244997400005
Scopus: 2-s2.0-33847270332
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PharmacyTY - JOUR AU - Vekić, Jelena AU - Topić, Aleksandra AU - Zeljković, Aleksandra AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/955 AB - Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P lt 0.001, and P lt 0.05, respectively), higher frequency of LDL B phenotype (P lt 0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P lt 0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P lt 0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population VL - 40 IS - 5-6 SP - 310 EP - 316 DO - 10.1016/j.clinbiochem.2006.11.013 ER -
@article{ author = "Vekić, Jelena and Topić, Aleksandra and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna", year = "2007", abstract = "Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P lt 0.001, and P lt 0.05, respectively), higher frequency of LDL B phenotype (P lt 0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P lt 0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P lt 0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population", volume = "40", number = "5-6", pages = "310-316", doi = "10.1016/j.clinbiochem.2006.11.013" }
Vekić, J., Topić, A., Zeljković, A., Jelić-Ivanović, Z.,& Spasojević-Kalimanovska, V.. (2007). LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 40(5-6), 310-316. https://doi.org/10.1016/j.clinbiochem.2006.11.013
Vekić J, Topić A, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V. LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population. in Clinical Biochemistry. 2007;40(5-6):310-316. doi:10.1016/j.clinbiochem.2006.11.013 .
Vekić, Jelena, Topić, Aleksandra, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, "LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population" in Clinical Biochemistry, 40, no. 5-6 (2007):310-316, https://doi.org/10.1016/j.clinbiochem.2006.11.013 . .