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dc.creatorVekić, Jelena
dc.creatorTopić, Aleksandra
dc.creatorZeljković, Aleksandra
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.date.accessioned2019-09-02T11:10:25Z
dc.date.available2019-09-02T11:10:25Z
dc.date.issued2007
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/955
dc.description.abstractObjectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P lt 0.001, and P lt 0.05, respectively), higher frequency of LDL B phenotype (P lt 0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P lt 0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P lt 0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectLDL particle sizeen
dc.subjectHDL particle sizeen
dc.subjectgradient gel electrophoresisen
dc.subjectFramingham risk scoreen
dc.titleLDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian populationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Векић, Јелена; Зељковић, Aлександра; Топић, Aлександра;
dc.citation.volume40
dc.citation.issue5-6
dc.citation.spage310
dc.citation.epage316
dc.citation.other40(5-6): 310-316
dc.citation.rankM22
dc.identifier.wos000244997400005
dc.identifier.doi10.1016/j.clinbiochem.2006.11.013
dc.identifier.pmid17291473
dc.identifier.scopus2-s2.0-33847270332
dc.identifier.rcubconv_1831
dc.type.versionpublishedVersion


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