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dc.creatorRadojević, Katarina
dc.creatorArsenović-Ranin, Nevena
dc.creatorKosec, Duško
dc.creatorPešić, V.
dc.creatorPilipović, Ivan
dc.creatorPerišić, M.
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:10:27Z
dc.date.available2019-09-02T11:10:27Z
dc.date.issued2007
dc.identifier.issn0022-0795
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/957
dc.description.abstractTo test putative interdependence in the ontogenesis of the hypothalamic-pituitary-gonadal and thymic-lymphatic axes, thymocyte differentiation and maturation was examined in neonatally castrated (Cx) adult rats. In the hypercellular thymi of Cx rats, the proportion of the least mature CD4(-)CD8(-)TCR alpha beta(-) triple negative (TN) thymocytes was reduced, while the proportions of all downstream double positive (DP) subsets (TCR alpha beta(-), TCR alpha beta(low) and TCR alpha beta(high)) were increased when compared with neonatally sham-castrated (Sx) adult rats. This suggested an accelerated thymocyte transition from the TN to DP TCR alpha beta(low) developmental stage accompanied by an increased positive/reduced negative thymocyte selection. The increased thymocyte surface density of Thy-1, which is implicated in thymocyte hyposensitivity to negative selection, in Cx rats further supports the previous assumption. The finding that the proportions of both single positive (SP) TCR alpha beta(high) thymocyte subsets were reduced, while their numbers were increased (CD4(+)CD8(-)) or unaltered (CD4(-)CD8(+)), coupled with results demonstrating an increased level of CD4(-)CD8(+) cells without changes in that of CD4(+) 8(-) cells in the spleen indicate: (i) accelerated differentiation and maturation of the positively selected DP TCR alpha beta(high) thymocytes towards CD4(-)8(+) TCR alpha beta(high) cells followed by increased emigration of the mature cells and (ii) decelerated hi h differentiation and maturation towards CD4(+)8(-) TCR alpha beta(high) cells in Cx rats. Furthermore, the unaltered proportion of intrathymically developing CD4(+)CD25(+)Foxp3(+) regulatory cells in Cx rats, in light of putative hyposensitivity of thymocytes to negative selection suggesting reduced elimination of autoreactive cells, may provide a firm basis for understanding the reasons behind increased susceptibility of Cx rats to autoimmune disease induction.en
dc.publisherBioscientifica Ltd, Bristol
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Endocrinology
dc.titleNeonatal castration affects intrathymic kinetics of T-cell differentiation and the spleen T-cell levelen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПешић, В.; Косец, Душко; Перишић, М.; Радојевић, Катарина; Лепосавић, Гордана; Aрсеновић-Ранин, Невена; Плећаш-Соларовић, Босиљка; Пилиповић, Иван;
dc.citation.volume192
dc.citation.issue3
dc.citation.spage669
dc.citation.epage682
dc.citation.other192(3): 669-682
dc.citation.rankM22
dc.identifier.wos000245123100019
dc.identifier.doi10.1677/joe.1.07019
dc.identifier.pmid17332534
dc.identifier.scopus2-s2.0-33947399305
dc.identifier.rcubconv_1833
dc.type.versionpublishedVersion


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