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Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach

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2007
Authors
Bogavac-Stanojević, Nataša
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Spasić, Slavica
Kalimanovska-Oštrić, Dimitra
Article (Published version)
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Abstract
Background: Many studies have investigated the clinical accuracy of single lipid and inflammatory markers. in contrast, few have evaluated their potential for the detection of CAD using a multi-marker approach. Methods: The concentrations of lipid, lipoproteins, apolipoproteins, high sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured by standard laboratory methods. Apolipoprotein (a) [apo(a)] phenotyping was performed by sodium dodecylsulphate-gel electrophoresis and immunoblotting. The lipid tetrad index (LTI) and the lipid pentad index (LPI) were calculated. Clinical accuracy of the examined parameters, indexes and a logistic regression model was assessed using receiving operative characteristic (ROC) curve analysis. Results: Logistic regression analysis indicated that non-HDL-c, hs-CRP, HDL-c and Lp(a) were significant independent predictors for CAD. The AUC for this model (0.802) was higher than AUCs for any single marker or index tested. Conclusions: We conclude ...that the performance of a logistic regression model for CAD prediction warrants its use in clinical practice.

Keywords:
apolipoprotein (a) / inflammatory markers / lipoprotein (a) / logistic regression model / receiver operating characteristic curve
Source:
Clinical Biochemistry, 2007, 40, 13-14, 1000-1006
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.clinbiochem.2007.05.012

ISSN: 0009-9120

PubMed: 17632095

WoS: 000249422200014

Scopus: 2-s2.0-34548152793
[ Google Scholar ]
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14
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/969
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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