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Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach
dc.creator | Bogavac-Stanojević, Nataša | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Spasić, Slavica | |
dc.creator | Kalimanovska-Oštrić, Dimitra | |
dc.date.accessioned | 2019-09-02T11:10:47Z | |
dc.date.available | 2019-09-02T11:10:47Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/969 | |
dc.description.abstract | Background: Many studies have investigated the clinical accuracy of single lipid and inflammatory markers. in contrast, few have evaluated their potential for the detection of CAD using a multi-marker approach. Methods: The concentrations of lipid, lipoproteins, apolipoproteins, high sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured by standard laboratory methods. Apolipoprotein (a) [apo(a)] phenotyping was performed by sodium dodecylsulphate-gel electrophoresis and immunoblotting. The lipid tetrad index (LTI) and the lipid pentad index (LPI) were calculated. Clinical accuracy of the examined parameters, indexes and a logistic regression model was assessed using receiving operative characteristic (ROC) curve analysis. Results: Logistic regression analysis indicated that non-HDL-c, hs-CRP, HDL-c and Lp(a) were significant independent predictors for CAD. The AUC for this model (0.802) was higher than AUCs for any single marker or index tested. Conclusions: We conclude that the performance of a logistic regression model for CAD prediction warrants its use in clinical practice. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | apolipoprotein (a) | en |
dc.subject | inflammatory markers | en |
dc.subject | lipoprotein (a) | en |
dc.subject | logistic regression model | en |
dc.subject | receiver operating characteristic curve | en |
dc.title | Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Богавац-Станојевић, Наташа; Јелић-Ивановић, Зорана; Калимановска-Оштрић, Димитра; Спасић, Славица; Спасојевић-Кахмановска, Весна; | |
dc.citation.volume | 40 | |
dc.citation.issue | 13-14 | |
dc.citation.spage | 1000 | |
dc.citation.epage | 1006 | |
dc.citation.other | 40(13-14): 1000-1006 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000249422200014 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2007.05.012 | |
dc.identifier.pmid | 17632095 | |
dc.identifier.scopus | 2-s2.0-34548152793 | |
dc.type.version | publishedVersion |